Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Review of PP2A Tumor Biology and Anti-Tumor Effects of PP2A Inhibitor LB100 in the Nervous System

Version 1 : Received: 11 May 2021 / Approved: 13 May 2021 / Online: 13 May 2021 (11:32:51 CEST)

A peer-reviewed article of this Preprint also exists.

Bryant, J.-P.; Levy, A.; Heiss, J.; Banasavadi-Siddegowda, Y.K. Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System. Cancers 2021, 13, 3087. Bryant, J.-P.; Levy, A.; Heiss, J.; Banasavadi-Siddegowda, Y.K. Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System. Cancers 2021, 13, 3087.

Journal reference: Cancers 2021, 13, 3087
DOI: 10.3390/cancers13123087

Abstract

Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system and dysregulation of its cellular functions are associated with myriad neurodegenerative disorders. Additionally, PP2A has oncologic implications, recently garnering attention and emerging as a therapeutic target because of the antitumor effects of a potent PP2A inhibitor, LB100. LB100 abrogation of PP2A is believed to exert its inhibitory effects on tumor progression through cellular chemo- and radio-sensitization to adjuvant agents. An updated and unifying review of PP2A biology and inhibition with LB100 as a therapeutic strategy for targeting cancers of the nervous system is needed, as other reviews have mainly covered broader applications of LB100. In this review, we discuss the role of PP2A in normal cells and tumor cells of the nervous system. Further, we summarize current evidence regarding the therapeutic potential of LB100 for treating solid tumors of the nervous system.

Keywords

PP2A; LB100; nervous system; tumor biology; brain tumor; preclinical; clinical trial

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