Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Design Optimization of Centrifugal Microfluidic "Lab-on-a-Disc" Systems towards Fluidic Larger-Scale Integration

Version 1 : Received: 12 May 2021 / Approved: 13 May 2021 / Online: 13 May 2021 (11:00:52 CEST)
Version 2 : Received: 7 June 2021 / Approved: 8 June 2021 / Online: 8 June 2021 (12:07:35 CEST)

How to cite: Ducrée, J. Design Optimization of Centrifugal Microfluidic "Lab-on-a-Disc" Systems towards Fluidic Larger-Scale Integration. Preprints 2021, 2021050282 (doi: 10.20944/preprints202105.0282.v2). Ducrée, J. Design Optimization of Centrifugal Microfluidic "Lab-on-a-Disc" Systems towards Fluidic Larger-Scale Integration. Preprints 2021, 2021050282 (doi: 10.20944/preprints202105.0282.v2).

Abstract

Enhancing the degree of functional multiplexing while assuring operational reliability and manufacturability at competitive costs are crucial ingredients for enabling comprehensive sample-to-answer automation, e.g., for use in common, decentralized “Point-of-Care” or “Point-of-Use” scenarios. This paper demonstrates a model-based ‘digital twin’ approach which efficiently supports the algorithmic design optimization of exemplary centrifugo-pneumatic (CP) dissolvable-film (DF) siphon valves towards larger-scale integration (LSI) of well-established “Lab-on-a-Disc” (LoaD) systems. Obviously, the spatial footprint of the valves and their upstream laboratory unit operations (LUOs) have to fit, at a given radial position prescribed by its occurrence in the assay protocol, into the locally accessible disc space. At the same time, the retention rate of a rotationally actuated CP-DF siphon valve and, most challenging, its band width related to unavoidable tolerances of experimental input parameters, need to slot into a defined interval of the practically allowed frequency envelope. To accomplish particular design goals, a set of parametrized metrics is defined, which are to be met within their practical boundaries while (numerically) minimizing the band width in the frequency domain. While each LSI scenario needs to be addressed individually on the basis of the digital twin, a suite of qualitative design rules and instructive showcases structures are presented.

Subject Areas

centrifugal microfluidics, Lab-on-a-Disc, large-scale integration, reliability, tolerances, band width, packing density

Comments (1)

Comment 1
Received: 8 June 2021
Commenter: Jens Ducrée
Commenter's Conflict of Interests: Author
Comment: Edits and updates in response to referee reports.
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