Brain mechanisms of COVID-19-sleep disorders

Oxana Semyachkina-Glushkovskaya; Aysel Mamedova; Valeria Vinnik; Maria Klimova; Tingting Yu; Dan Zhu; Thomas Penzel; Jurgen Kurths

doi:10.20944/preprints202105.0099.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 4 May 2021 / Approved: 6 May 2021 / Online: 6 May 2021 (15:09:41 CEST)

Here, we review findings and trends in sleep research in 2020-2021 demonstrating how COVID-19 and sleep disorders can induce the BBB leakage via neuroinflammation, which might contribute to the 'coronasomnia' phenomenon. The new studies suggest that the controlling of sleep hygiene and quality should be incorporated into the rehabilitation of COVID-19 patients. We also discuss perspective strategies for prevention of COVID-19-related BBB disorders. We demonstrate that sleep might be a novel biomarker of the BBB leakage and the analysis of sleep EEG patterns can be a breakthrough non-invasive technology for diagnosis of the COVID-19-caused BBB disruption.

COVID-19-sleep disorders; brain mechanisms; the blood-brain barrier permeability.

Biology and Life Sciences, Anatomy and Physiology

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Brain mechanisms of COVID-19-sleep disorders

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