Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

African Trypanosomosis Permanently Obliterates DTPa Vaccine Induced Memory so That Post-treatment Bordetella Pertussis Challenge Fails to Trigger a Protective Recall Response

Version 1 : Received: 29 April 2021 / Approved: 30 April 2021 / Online: 30 April 2021 (10:40:55 CEST)

A peer-reviewed article of this Preprint also exists.

Radwanska, M.; Nguyen, H.T.T.; Magez, S. African Trypanosomosis Obliterates DTPa Vaccine-Induced Functional Memory So That Post-treatment Bordetella pertussis Challenge Fails to Trigger a Protective Recall Response. Vaccines 2021, 9, 603. Radwanska, M.; Nguyen, H.T.T.; Magez, S. African Trypanosomosis Obliterates DTPa Vaccine-Induced Functional Memory So That Post-treatment Bordetella pertussis Challenge Fails to Trigger a Protective Recall Response. Vaccines 2021, 9, 603.

Journal reference: Vaccines 2021, 9, 603
DOI: 10.3390/vaccines9060603

Abstract

Salivarian trypanosomes are extracellular parasites causing anthroponotic and zoonotic infections. Anti-parasite vaccination in considered the only sustainable method for global trypanosomosis control. Unfortunately, not a single field applicable vaccine solution has been successful so far. Active destruction of the host’s adaptive immune system by trypanosomes is believed to contribute to this problem. Here we show Trypanosome brucei brucei infection results in the lasting obliteration of immunological memory, including vaccine-induced memory against non-related pathogens. Using the well-established DTPa vaccine model in combination with a T. b. brucei infection and diminazene diaceturate anti-parasite treatment scheme, our result demonstrate that while the latter ensured the full recovery from the T. b. brucei infection, it failed to restore an efficacious anti-pertussis vaccine recall response. DTPa vaccine failure coincided with a shift in the IgG1/IgG2a anti-pertussis antibody ratio in favor of the latter, and a striking impact on all spleen immune cell populations. Interestingly, an increased plasma IFNy level in DTPa vaccinated trypanosome infected mice did result in a temporary antibody-independent improvement of early-stage trypanosomosis control. In conclusion, our results are the first to show that trypanosome inflicted immune damage is permanent, and is not restored by successful anti-parasite treatment.

Subject Areas

Trypanosomosis; Treatment; DTPa; Bordetella pertussis 3

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