Preserved in Portico This version is not peer-reviewed
Popular Ethnomedicinal Plant Alstonia scholaris Induces Neurotoxicity-related Behavioural Changes in Swiss Albino Mice
: Received: 27 April 2021 / Approved: 29 April 2021 / Online: 29 April 2021 (07:45:20 CEST)
A peer-reviewed article of this Preprint also exists.
Journal reference: Austin Neurology 2021, 4, 1016
Plants constituents are a reliable source of the remedial need of humanity for ages by being the basis of the traditional medicinal system and often serving as the prototype for designing modern medicine. Several plants are used in traditional medicine for ages without proper administration guidelines in terms of dosages. Several toxicological analyses revealed side-effects of such therapies beyond a specific dose. One such plant is Alstonia scholaris, widely used in numerous traditional medicines to treat diseases like ulcers, asthma, diabetes, etc. The present study investigated the neurotoxic effect of the plant extract through oxidative stress in Swiss albino mice. The treated mice showed anxiety, neophobic and depression-like properties compared to control mice. The biochemical parameters show an increase in Malondialdehyde (MDA) concentration while decreasing the total protein content in different brain regions of treated mice. The Glutathione Reductase (GR) activity shows an increase in treated mice compared to the control one. The study indicates that Alstonia scholaris may cause severe damage to the central nervous system when administered without a proper guideline.
Alstonia scholaris; Neurotoxicity; in-vivo; Malondialdehyde; Glutathione Reductase
LIFE SCIENCES, Biochemistry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.