Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Having an Old Friend For Dinner: The Interplay between Apoptotic Cells and Efferocytes

Version 1 : Received: 26 April 2021 / Approved: 28 April 2021 / Online: 28 April 2021 (15:28:24 CEST)

A peer-reviewed article of this Preprint also exists.

Lam, A.L.; Heit, B. Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and Efferocytes. Cells 2021, 10, 1265. Lam, A.L.; Heit, B. Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and Efferocytes. Cells 2021, 10, 1265.

Journal reference: Cells 2021, 10, 1265
DOI: 10.3390/cells10051265

Abstract

Apoptosis, the programmed and intentional death of senescent, damaged, or otherwise superfluous cells, is the natural end-point for most cells within multicellular organisms. Apoptotic cells are not inherently damaging, but if left unattended they can lyse through secondary necrosis. The resulting release of intracellular contents drives inflammation in the surrounding tissue and can lead to autoimmunity. These negative consequences of secondary necrosis are avoided by efferocytosis—the phagocytic clearance of apoptotic cells. Efferocytosis is a product of both apoptotic cell and efferocyte mechanisms, which cooperate to ensure the rapid and complete removal of apoptotic cells. Herein, the processes used by apoptotic cells to ensure their timely removal, and the receptors, signaling, and cellular processes used by efferocytes to identify, remove, and process the apoptotic cells, are reviewed.

Subject Areas

efferocytosis; cell death; apoptosis; intracellular trafficking; transcriptional regulation; cellular metabolism; inflammation; resolution

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