Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Secure Air Traffic Control at the Hub of Multiplexing on the Centrifugo-Pneumatic Lab-on-a-Disc Platform

Version 1 : Received: 20 April 2021 / Approved: 22 April 2021 / Online: 22 April 2021 (14:07:56 CEST)
Version 2 : Received: 7 June 2021 / Approved: 8 June 2021 / Online: 8 June 2021 (11:23:58 CEST)

A peer-reviewed article of this Preprint also exists.

Ducrée, J. Secure Air Traffic Control at the Hub of Multiplexing on the Centrifugo-Pneumatic Lab-On-a-Disc Platform. Micromachines 2021, 12, 700. Ducrée, J. Secure Air Traffic Control at the Hub of Multiplexing on the Centrifugo-Pneumatic Lab-On-a-Disc Platform. Micromachines 2021, 12, 700.

Journal reference: Micromachines 2021, 12, 700
DOI: 10.3390/mi12060700

Abstract

Fluidic larger-scale integration (LSI) resides at the heart of comprehensive sample-to-answer automation and parallelization of assay panels for frequent and ubiquitous bioanalytical testing in decentralized the point-of-use / point-of-care settings. This paper develops a novel “digital twin” strategy with an emphasis on rotational, centrifugo-pneumatic flow control. The underlying model systematically connects retention rates of rotationally actuated valves as a key element of LSI to experimental input parameters; for the first time, the concept of band widths in frequency space as the decisive quantity characterizing operationally robustness is introduced, a set of quantitative performance metrics guiding algorithmic optimization of disc layouts is defined, and the engineering principles of advanced, logical flow control and timing are elucidated. Overall, the digital twin enables efficient design for automating multiplexed bioassay protocols on such “Lab-on-a-Disc” (LoaD) systems featuring high packing density, reliability, configurability, modularity and manufacturability to eventually minimize cost, time and risk of development and production.

Subject Areas

centrifugal microfluidics; Lab-on-a-Disc; centrifugo-pneumatic flow control; integration; multiplexing; parallelization; sample-to-answer; reliability; tolerances; design-for-manufacture; digital twin; event-triggering

Comments (1)

Comment 1
Received: 8 June 2021
Commenter: Jens Ducrée
Commenter's Conflict of Interests: Author
Comment: Updates and edits in response to referee reports.
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