Version 1
: Received: 19 April 2021 / Approved: 19 April 2021 / Online: 19 April 2021 (11:52:31 CEST)
Version 2
: Received: 19 April 2021 / Approved: 20 April 2021 / Online: 20 April 2021 (11:48:02 CEST)
Aoki, K.; Suzuki, T.; Hui, F.; Nakano, T.; Yanazawa, K.; Yonamine, M.; Fujita, S.; Sugasawa, T.; Yoshida, Y.; Omi, N.; Kawakami, Y.; Takekoshi, K. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice. Nutrients2021, 13, 1735.
Aoki, K.; Suzuki, T.; Hui, F.; Nakano, T.; Yanazawa, K.; Yonamine, M.; Fujita, S.; Sugasawa, T.; Yoshida, Y.; Omi, N.; Kawakami, Y.; Takekoshi, K. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice. Nutrients 2021, 13, 1735.
Aoki, K.; Suzuki, T.; Hui, F.; Nakano, T.; Yanazawa, K.; Yonamine, M.; Fujita, S.; Sugasawa, T.; Yoshida, Y.; Omi, N.; Kawakami, Y.; Takekoshi, K. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice. Nutrients2021, 13, 1735.
Aoki, K.; Suzuki, T.; Hui, F.; Nakano, T.; Yanazawa, K.; Yonamine, M.; Fujita, S.; Sugasawa, T.; Yoshida, Y.; Omi, N.; Kawakami, Y.; Takekoshi, K. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice. Nutrients 2021, 13, 1735.
Abstract
Exercise affects various organs. However, its effects on nutrient digestion and absorption in the intestinal tract are not well understood. A few studies have reported that exercise training in-creases the expression of carbohydrate digestion and absorption molecules. Exercise was also shown to increase the concentration of blood glucagon like peptide-2(GLP-2), which regulates carbohydrate digestion and absorption in small intestinal epithelium. Therefore, we investigated the effects of exercise on intestinal digestion and absorption molecules and the levels of GLP-2. 6-wk-old of male mice were divided into 2 groups; sedentary (SED) and low-intensity exercise (LEx). LEx mice were required to run on a treadmill (12.5 m/min, 60 min), whereas SED mice rested. All mice were euthanized 1 h after exercise or rest and plasma, jejunum, ileum, and colon were sampled. Samples were analyzed using EIA and immunoblotting. The levels of plasma GLP-2 and the expression of the GLP-2 receptor, sucrase-isomaltase (SI), and glucose transporter (GLUT2) in the jejunum were increased in LEx group. We showed that acute low-intensity exer-cise affects the intestinal carbohydrate digestion and absorption molecules via GLP-2. Our results suggest that exercise might provide new benefits to the small intestine for people with intestinal frailty.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Kai Aoki
Commenter's Conflict of Interests: Author