Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

Version 1 : Received: 14 April 2021 / Approved: 15 April 2021 / Online: 15 April 2021 (18:12:26 CEST)

How to cite: Debons, N.; Matsumoto, K.; Hirota, N.; Coradin, T.; Ikoma, T.; Aimé, C. Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials. Preprints 2021, 2021040426 (doi: 10.20944/preprints202104.0426.v1). Debons, N.; Matsumoto, K.; Hirota, N.; Coradin, T.; Ikoma, T.; Aimé, C. Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials. Preprints 2021, 2021040426 (doi: 10.20944/preprints202104.0426.v1).

Abstract

Major progress in the field of regenerative medicine are expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from Tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances.

Subject Areas

bionanocomposites; collagen; high magnetic field; silica particles

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