Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials

Nicolas Debons
,
Kenta Matsumoto
,
Noriyuki Hirota
,
Thibaud Coradin
ORCID logo ,
Toshiyuki Ikoma
,
Carole Aimé
*
Version 1 : Received: 14 April 2021 / Approved: 15 April 2021 / Online: 15 April 2021 (18:12:26 CEST)

A peer-reviewed article of this Preprint also exists.

Debons, N.; Matsumoto, K.; Hirota, N.; Coradin, T.; Ikoma, T.; Aimé, C. Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials. Biomolecules 2021, 11, 749. Debons, N.; Matsumoto, K.; Hirota, N.; Coradin, T.; Ikoma, T.; Aimé, C. Magnetic Field Alignment, a Perspective in the Engineering of Collagen-Silica Composite Biomaterials. Biomolecules 2021, 11, 749.

Abstract

Major progress in the field of regenerative medicine are expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from Tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances.

Keywords

bionanocomposites; collagen; high magnetic field; silica particles

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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