Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Interconnected High-Dimensional Landscapes of Epithelial-Mesenchymal Plasticity and Stemness

Version 1 : Received: 14 April 2021 / Approved: 15 April 2021 / Online: 15 April 2021 (12:57:56 CEST)

How to cite: Sahoo, S.; Duddu, A.S.; Biddle, A.; Jolly, M.K. Interconnected High-Dimensional Landscapes of Epithelial-Mesenchymal Plasticity and Stemness. Preprints 2021, 2021040415 (doi: 10.20944/preprints202104.0415.v1). Sahoo, S.; Duddu, A.S.; Biddle, A.; Jolly, M.K. Interconnected High-Dimensional Landscapes of Epithelial-Mesenchymal Plasticity and Stemness. Preprints 2021, 2021040415 (doi: 10.20944/preprints202104.0415.v1).

Abstract

Establishing macrometastases at distant organs is a highly challenging process for cancer cells, with extremely high attrition rates. A very small percentage of disseminated cells have the ability to dynamically adapt to their changing micro-environments through reversibly switching to another phenotype, aiding metastasis. Such plasticity can be exhibited along one or more axes – epithelial-mesenchymal plasticity (EMP) and cancer stem cells (CSCs) being the two most studied, and often tacitly assumed to be synonymous. Here, we review the emerging concepts related to EMP and CSCs across multiple cancers. Both processes are multi-dimensional in nature; for instance, EMP can be defined on morphological, molecular and functional changes, which may or may not be synchronized. Similarly, self-renewal, multi-lineage potential, and anoikis and/or therapy resistance may not all occur simultaneously in CSCs. Thus, arriving at rigorous functional definitions for both EMP and CSCs is crucial. These processes are dynamic, reversible, and semi-independent in nature; cells traverse the inter-connected high-dimensional EMP and CSC landscapes in diverse paths, each of which may exhibit a distinct EMP-CSC coupling. Our proposed model offers a potential unifying framework for elucidating the coupled decision-making along these dimensions and highlights a key set of open questions to be answered.

Subject Areas

epithelial-mesenchymal plasticity; stemness; landscape; phenotypic plasticity; cancer stem cells; metastasis

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.