Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Efficacy of Bacteriophage in Removal of Pseudomonas aeruginosa from Infectious Surfaces

Version 1 : Received: 14 April 2021 / Approved: 15 April 2021 / Online: 15 April 2021 (12:23:49 CEST)

How to cite: Rahimzadeh, G.; Rezai, M.S. Efficacy of Bacteriophage in Removal of Pseudomonas aeruginosa from Infectious Surfaces. Preprints 2021, 2021040411 (doi: 10.20944/preprints202104.0411.v1). Rahimzadeh, G.; Rezai, M.S. Efficacy of Bacteriophage in Removal of Pseudomonas aeruginosa from Infectious Surfaces. Preprints 2021, 2021040411 (doi: 10.20944/preprints202104.0411.v1).

Abstract

Nosocomial infections can be transmitted by contaminated hospital surfaces with resistant pathogens. conventional sanitations are not efficiently contributing to removing resistant pathogens. Bacteriophages suggest as decontaminating agents, safe, their selective ability to kill specific bacteria. This work aimed to assess the efficiency of a phage in removing Pseudomonas aeruginosa from different hard surfaces. The decontamination ability of phages w was tested in vitro against Pseudomonas aeruginosa strain. Cystoviridae Phages with titer (2 × 1012 PFU/mL) can efficiently reduce viable bacterial cells on contaminated surfaces. The treated surfaces with alcohol 70% and phage showed an evident drop of bacterial cell number from 1 h to 24 h. These results suggest that bacteriophages are biocontrol agents removing nosocomial infection pathogens transmitted by contaminated surfaces in the hospital environment.

Keywords

pseudomonas aeruginosa; nosocomial infections; decontamination; phage

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