Version 1
: Received: 10 April 2021 / Approved: 13 April 2021 / Online: 13 April 2021 (10:12:52 CEST)
Version 2
: Received: 13 April 2021 / Approved: 13 April 2021 / Online: 13 April 2021 (13:14:55 CEST)
Pliquett, R.U.; Tannapfel, A.; Daneschnejad, S.S. Renal Allograft-Related Inflammation Complicated by Acute Coronary Syndromes. Medicine 2021, 100, e28205, doi:10.1097/md.0000000000028205.
Pliquett, R.U.; Tannapfel, A.; Daneschnejad, S.S. Renal Allograft-Related Inflammation Complicated by Acute Coronary Syndromes. Medicine 2021, 100, e28205, doi:10.1097/md.0000000000028205.
Pliquett, R.U.; Tannapfel, A.; Daneschnejad, S.S. Renal Allograft-Related Inflammation Complicated by Acute Coronary Syndromes. Medicine 2021, 100, e28205, doi:10.1097/md.0000000000028205.
Pliquett, R.U.; Tannapfel, A.; Daneschnejad, S.S. Renal Allograft-Related Inflammation Complicated by Acute Coronary Syndromes. Medicine 2021, 100, e28205, doi:10.1097/md.0000000000028205.
Abstract
Background: Although persistent systemic inflammation is considered to be predictive for future cardiovascular events, it remains unclear whether or not C-reactive protein (CrP) plays an active role in coronary-plaque instability. Here, we report a case of a patient with failed and super-infected renal allograft as a source for systemic inflammation presenting with repeat acute coronary syndromes.Case presentation: A 52-years-old male type-2 diabetic with a failed kidney transplant who was hospitalized for acute urinary-tract infection. In the presence of other, classic cardiovascular risk factors, peak values of CrP coincided with episodes of unstable angina treated by percutaneous coronary interventions. Besides pyelonephritis, the histological examination of the kidney transplant revealed signs of chronic rejection and the presence of a renal cell carcinoma in situ. Once the renal allograft has been removed, systemic inflammation was attenuated, the patient was not re-hospitalized for acute-coronary syndrome within the next 12 months.Conclusion: In this case, systemic inflammation was paralleled by instability of coronary plaques as documented by repeat percutaneous coronary interventions.
Keywords
coronary artery disease, acute coronary syndrome, inflammation, case report
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Rainer U Pliquett
Commenter's Conflict of Interests: Author