Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Renal Allograft-Related Inflammation and Accelerated Coronary-Artery Disease: A Case Report

Version 1 : Received: 10 April 2021 / Approved: 13 April 2021 / Online: 13 April 2021 (10:12:52 CEST)
Version 2 : Received: 13 April 2021 / Approved: 13 April 2021 / Online: 13 April 2021 (13:14:55 CEST)

How to cite: Pliquett, R.U.; Tannapfel, A.; Daneschnejad, S.S. Renal Allograft-Related Inflammation and Accelerated Coronary-Artery Disease: A Case Report. Preprints 2021, 2021040337 (doi: 10.20944/preprints202104.0337.v1). Pliquett, R.U.; Tannapfel, A.; Daneschnejad, S.S. Renal Allograft-Related Inflammation and Accelerated Coronary-Artery Disease: A Case Report. Preprints 2021, 2021040337 (doi: 10.20944/preprints202104.0337.v1).

Abstract

Background: Although persistent systemic inflammation is considered to be predictive for future cardiovascular events, it remains unclear whether or not C-reactive protein (CrP) plays an active role in coronary-plaque instability. Here, we report a case of a patient with failed and super-infected renal allograft as a source for systemic inflammation presenting with repeat acute coronary syndromes. Case presentation: A 52-years-old male type-2 diabetic with a failed kidney transplant who was hospitalized for acute urinary-tract infection. In the presence of other, classic cardiovascular risk factors, peak values of CrP coincided with episodes of unstable angina treated by cardiologic interventions. Besides pyelonephritis, the histological examination of the kidney transplant revealed signs of chronic rejection and the presence of a renal cell carcinoma in situ. Once the renal allograft has been removed, systemic inflammation was attenuated, the patient was not rehospitalized for acute-coronary syndrome within the next 12 months. Conclusion: In this case, systemic inflammation was paralleled by instability of coronary plaques as documented by repeat coronary angiograms.

Keywords

coronary artery disease, acute coronary syndrome, inflammation, case report

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