Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise

Version 1 : Received: 5 April 2021 / Approved: 7 April 2021 / Online: 7 April 2021 (11:25:59 CEST)
Version 2 : Received: 7 April 2021 / Approved: 8 April 2021 / Online: 8 April 2021 (10:51:11 CEST)

A peer-reviewed article of this Preprint also exists.

Duerr, R.; Crosse, K.M.; Valero-Jimenez, A.M.; Dittmann, M. SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise. Microorganisms 2021, 9, 1389. Duerr, R.; Crosse, K.M.; Valero-Jimenez, A.M.; Dittmann, M. SARS-CoV-2 Portrayed against HIV: Contrary Viral Strategies in Similar Disguise. Microorganisms 2021, 9, 1389.

Abstract

SARS-CoV-2 and HIV are zoonotic viruses that rapidly reached pandemic scale causing global losses and fear. The COVID-19 and AIDS pandemics ignited massive efforts worldwide to develop antiviral strategies and characterize viral architectures, biological and immunological properties, and clinical outcomes. Although both viruses have a comparable appearance as enveloped viruses with positive-stranded RNA and envelope spikes mediating cellular entry, the entry process, downstream biological and immunological pathways, clinical outcomes, and disease courses are strikingly different. This review provides a systemic comparison of both viruses’ structural and functional characteristics delineating their distinct strategies for efficient spread.

Keywords

SARS-CoV-2; HIV; zoonotic viruses; COVID-19 and AIDS pandemics; viral entry

Subject

Biology and Life Sciences, Virology

Comments (1)

Comment 1
Received: 8 April 2021
Commenter: Ralf Duerr
Commenter's Conflict of Interests: Author
Comment: Baltimore virus classification added to Table 1 and text body.
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