Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise

Version 1 : Received: 5 April 2021 / Approved: 7 April 2021 / Online: 7 April 2021 (11:25:59 CEST)
Version 2 : Received: 7 April 2021 / Approved: 8 April 2021 / Online: 8 April 2021 (10:51:11 CEST)

How to cite: Duerr, R.; Crosse, K.M.; Valero Jimenez, A.M.; Dittmann, M. SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise. Preprints 2021, 2021040193 (doi: 10.20944/preprints202104.0193.v2). Duerr, R.; Crosse, K.M.; Valero Jimenez, A.M.; Dittmann, M. SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise. Preprints 2021, 2021040193 (doi: 10.20944/preprints202104.0193.v2).

Abstract

SARS-CoV-2 and HIV are zoonotic viruses that rapidly reached pandemic scale causing global losses and fear. The COVID-19 and AIDS pandemics ignited massive efforts worldwide to develop antiviral strategies and characterize viral architectures, biological and immunological properties, and clinical outcomes. Although both viruses have a comparable appearance as enveloped viruses with positive-stranded RNA and envelope spikes mediating cellular entry, the entry process, downstream biological and immunological pathways, clinical outcomes, and disease courses are strikingly different. This review provides a systemic comparison of both viruses’ structural and functional characteristics delineating their distinct strategies for efficient spread.

Subject Areas

SARS-CoV-2; HIV; zoonotic viruses; COVID-19 and AIDS pandemics; viral entry

Comments (1)

Comment 1
Received: 8 April 2021
Commenter: Ralf Duerr
Commenter's Conflict of Interests: Author
Comment: Baltimore virus classification added to Table 1 and text body.
+ Respond to this comment

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 1
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.