Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Intracellular Interactions between Arboviruses and Wolbachia in Aedes aegypti

Version 1 : Received: 2 April 2021 / Approved: 5 April 2021 / Online: 5 April 2021 (16:00:03 CEST)

A peer-reviewed article of this Preprint also exists.

Reyes, J. I. L., Suzuki, Y., Carvajal, T., Muñoz, M. N. M., and Watanabe, K. (2021). Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti. Front. Cell. Infect. Microbiol. 11. doi:10.3389/fcimb.2021.690087. Reyes, J. I. L., Suzuki, Y., Carvajal, T., Muñoz, M. N. M., and Watanabe, K. (2021). Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti. Front. Cell. Infect. Microbiol. 11. doi:10.3389/fcimb.2021.690087.

Journal reference: Frontiers in Cellular and Infection Microbiology 2021
DOI: 10.3389/fcimb.2021.690087

Abstract

Aedes aegypti is inherently susceptible to arboviruses. The geographical expansion of this vector host species has led to the persistence of Dengue, Zika and Chikungunya human infections. These viruses take advantage of the mosquito’s cell to create an environment conducive for their growth. Arboviral infection triggers transcriptomic and protein dysregulation in Ae. aegypti and in effect, host antiviral mechanisms are compromised. Currently, there are no existing vaccines able to protect human hosts from these infections and thus, vector control strategies such as Wolbachia mass release program is regarded as a viable option. Considerable evidence demonstrates how the presence of Wolbachia interferes with arboviruses by decreasing cellular components vital for the pathogen and strengthening antiviral host responses. However, variation in the magnitude of Wolbachia’s viral inhibition that is neither due to strain nor density has been observed. Furthermore, the cellular mechanisms involved in the endosymbiont’s pathogen-blocking differs among hosts. This prompts the need to explore the cellular interactions between Ae. aegypti-arboviruses-Wolbachia and how these interactions overall affect the mosquito’s cell. Understanding what happens at the cellular and molecular level will provide evidence on the sustainability of Wolbachia vector control.

Keywords

Aedes aegypti; Dengue; Zika; Chikungunya; Wolbachia; Vector control

Subject

LIFE SCIENCES, Biochemistry

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