Reyes, J. I. L., Suzuki, Y., Carvajal, T., Muñoz, M. N. M., and Watanabe, K. (2021). Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti. Front. Cell. Infect. Microbiol. 11. doi:10.3389/fcimb.2021.690087.
Reyes, J. I. L., Suzuki, Y., Carvajal, T., Muñoz, M. N. M., and Watanabe, K. (2021). Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti. Front. Cell. Infect. Microbiol. 11. doi:10.3389/fcimb.2021.690087.
Reyes, J. I. L., Suzuki, Y., Carvajal, T., Muñoz, M. N. M., and Watanabe, K. (2021). Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti. Front. Cell. Infect. Microbiol. 11. doi:10.3389/fcimb.2021.690087.
Reyes, J. I. L., Suzuki, Y., Carvajal, T., Muñoz, M. N. M., and Watanabe, K. (2021). Intracellular Interactions Between Arboviruses and Wolbachia in Aedes aegypti. Front. Cell. Infect. Microbiol. 11. doi:10.3389/fcimb.2021.690087.
Abstract
Aedes aegypti is inherently susceptible to arboviruses. The geographical expansion of this vector host species has led to the persistence of Dengue, Zika and Chikungunya human infections. These viruses take advantage of the mosquito’s cell to create an environment conducive for their growth. Arboviral infection triggers transcriptomic and protein dysregulation in Ae. aegypti and in effect, host antiviral mechanisms are compromised. Currently, there are no existing vaccines able to protect human hosts from these infections and thus, vector control strategies such as Wolbachia mass release program is regarded as a viable option. Considerable evidence demonstrates how the presence of Wolbachia interferes with arboviruses by decreasing cellular components vital for the pathogen and strengthening antiviral host responses. However, variation in the magnitude of Wolbachia’s viral inhibition that is neither due to strain nor density has been observed. Furthermore, the cellular mechanisms involved in the endosymbiont’s pathogen-blocking differs among hosts. This prompts the need to explore the cellular interactions between Ae. aegypti-arboviruses-Wolbachia and how these interactions overall affect the mosquito’s cell. Understanding what happens at the cellular and molecular level will provide evidence on the sustainability of Wolbachia vector control.
Keywords
Aedes aegypti; Dengue; Zika; Chikungunya; Wolbachia; Vector control
Subject
LIFE SCIENCES, Biochemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
