Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Classical and microRNA Regulated Epigenetic Mechanisms as Potential Mediators of the Metabolic Syndrome

Version 1 : Received: 1 April 2021 / Approved: 2 April 2021 / Online: 2 April 2021 (14:08:11 CEST)

A peer-reviewed article of this Preprint also exists.

Ramzan, F.; Vickers, M.H.; Mithen, R.F. Epigenetics, microRNA and Metabolic Syndrome: A Comprehensive Review. Int. J. Mol. Sci. 2021, 22, 5047. Ramzan, F.; Vickers, M.H.; Mithen, R.F. Epigenetics, microRNA and Metabolic Syndrome: A Comprehensive Review. Int. J. Mol. Sci. 2021, 22, 5047.

Journal reference: Int. J. Mol. Sci. 2021, 22, 5047
DOI: 10.3390/ijms22095047

Abstract

Epigenetics refers to the DNA chemistry changes that result in the modification of gene transcription and translation independently of the underlying DNA coding sequence. Epigenetic modifications are reported to involve various molecular mechanisms, including classical epigenetic changes affecting DNA methylation and histone modifications and small RNA-mediated processes, particularly that of microRNAs. Epigenetic changes are reversible and are closely interconnected. They are recognised to play a critical role as mediators of gene regulation, and any alteration in these mechanisms has been identified to mediate various pathophysiological conditions. Moreover, genetic predisposition and environmental factors, including dietary alterations, lifestyle or metabolic status, are identified to interact with the human epigenome, highlighting the importance of epigenetic factors as underlying processes in the etiology of various diseases such as MetS. This review will reflect on how both the classical and microRNA regulated epigenetic changes are associated with the pathophysiology of Metabolic syndrome. We would then focus on the various aspects of epigenetic-based strategies used to modify MetS outcomes, including epigenetic diet, epigenetic drugs, epigenome editing tools, and miRNA-based therapies.

Keywords

DNA methylation; histone modification; epigenetic diet; microRNAs; prediabetes

Subject

LIFE SCIENCES, Biochemistry

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