Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures

Version 1 : Received: 31 March 2021 / Approved: 1 April 2021 / Online: 1 April 2021 (17:32:58 CEST)
Version 2 : Received: 6 April 2021 / Approved: 7 April 2021 / Online: 7 April 2021 (10:13:48 CEST)
Version 3 : Received: 12 April 2021 / Approved: 12 April 2021 / Online: 12 April 2021 (16:19:44 CEST)
Version 4 : Received: 15 April 2021 / Approved: 15 April 2021 / Online: 15 April 2021 (14:07:15 CEST)

How to cite: Perez, J. SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures. Preprints 2021, 2021040034 (doi: 10.20944/preprints202104.0034.v1). Perez, J. SARS-CoV2 Variants and Vaccines mRNA Spikes Fibonacci Numerical UA/CG Metastructures. Preprints 2021, 2021040034 (doi: 10.20944/preprints202104.0034.v1).

Abstract

In this paper, we suggest a biomathematical numerical method analysing mRNA nucleotides sequences based on UA/CG Fibonacci numbers proportions. This method is used to evaluate then compare the spike genes related to the main SARS-CoV2 VARIANTS circulating presently within the world. The 8 main results proposed to be reproduced by peers are: 1/ SARS-CoV2 genome and spike evolution in one year 2020-2021. 2/ SARS-CoV2 Origins. 3/ Comparing 11 reference variants spikes. 4/ analysing 32 CAL.20C california variant patients spikes. 5/ Toward a meta mRNA Fibonacci gene end message code. 6/ analysing S501 UK, S484 South Afrika and 2 mutations IINDIA variants. 7/ Suggesting a possible variants spike mRNA palindrome symmetry metastructure improving mRNA stability then infectuosity. 8/ Analysing Fibonacci Metastructures in the mRNA coding for the vaccines PFITZER and MODERNA. Particularly, we suggest the following conjecture at mRNA folding level: CONJECTURE of SARS-CoV2 VARIANTS: The growth of long Fibonacci structures in the shape of podiums for almost all of the variants studied (UK, California, South Afrika, India, etc.) suggests the probable folding of the Spike mRNA in the form of a hairpin, which can strengthen the cohesion and the lifespan of this mRNA. Finally, we show that this kind of Fibonacci matastructures disapears TOTALLY analysing the published mRNA sequences of PFITZER and MODERNA vaccines.

Subject Areas

SARS-CoV2; Biomathematics; vaccine; variants; mRNA; Fibonacci

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