Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

CD137 Signaling is Critical in Fungal Clearance During Systemic Candida albicans Infection

Version 1 : Received: 26 March 2021 / Approved: 29 March 2021 / Online: 29 March 2021 (09:47:02 CEST)

How to cite: Tran, V.V.G.; Nguyen, Z.N.N.; Kwon, B. CD137 Signaling is Critical in Fungal Clearance During Systemic Candida albicans Infection. Preprints 2021, 2021030677 (doi: 10.20944/preprints202103.0677.v1). Tran, V.V.G.; Nguyen, Z.N.N.; Kwon, B. CD137 Signaling is Critical in Fungal Clearance During Systemic Candida albicans Infection. Preprints 2021, 2021030677 (doi: 10.20944/preprints202103.0677.v1).

Abstract

Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance at the early phase of infections, yet little has been known regarding which surface receptor controls neutrophil phagocytic activities during systemic C. albicans infection. CD137, which is encoded by Tnfrsf9, belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Here, we used genetic and immunological tools to probe the involvement of CD137 signaling in innate defense mechanisms against systemic C. albicans infection. We first found that Tnfrsf9-/- mice were susceptible to C. albicans infection, whereas injection of anti-CD137 agonistic antibody protected the host from infection, suggesting that CD137 signaling is indispensable for innate immunity against C. albicans infection. Priming of isolated neutrophils with anti-CD137 antibody promoted their phagocytic and fungicidal activities through phospholipase C. In addition, injection of anti-CD137 antibody significantly augmented restriction of fungal growth in Tnfrsf9-/- mice that received WT neutrophils. In conclusion, our results demonstrate that CD137 signaling contributes to defense mechanisms against systemic C. albicans infection by promoting rapid fungal clearance whereby harmful immunopathology-induced tissue injuries are minimalized.

Subject Areas

Candida albicans; CD137; neutrophil; fungal clearance

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.