Wazzani, R.; Pallu, S.; Bourzac, C.; Ahmaïdi, S.; Portier, H.; Jaffré, C. Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context? Life2021, 11, 783.
Wazzani, R.; Pallu, S.; Bourzac, C.; Ahmaïdi, S.; Portier, H.; Jaffré, C. Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context? Life 2021, 11, 783.
Wazzani, R.; Pallu, S.; Bourzac, C.; Ahmaïdi, S.; Portier, H.; Jaffré, C. Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context? Life2021, 11, 783.
Wazzani, R.; Pallu, S.; Bourzac, C.; Ahmaïdi, S.; Portier, H.; Jaffré, C. Physical Activity and Bone Vascularization: A Way to Explore in Bone Repair Context? Life 2021, 11, 783.
Abstract
Physical activity is widely recognized as a biotherapy by WHO in the fight and prevention of bone diseases such as osteoporosis. It reduces the risk of disabling fractures associated with many comorbidities, and whose repair is a major public health and economic issue. Bone tissue is a dynamic supportive tissue that reshapes itself according to the mechanical stresses to which it is exposed. Physical exercise is recognized as a key factor for bone health. However, the effects of exercise on bone quality depend on exercise protocols, duration, intensity and frequency. Today, the effects of different exercise modalities on capillary bone vascularization, bone blood flow and bone angiogenesis remain poorly understood and unclear. As vascularization is an integral part of bone repair process, the analysis of the preventive and/or curative effects of physical exercise is currently very undeveloped. Angiogenesis-osteogenesis coupling may constitute a new way for understanding the role of physical activity, especially in fracturing or in the integration of bone biomaterials. Thus, this review aims to clarify the link between physical activities, vascularization and bone repair.
Keywords
Physical activity; bone vascularization; angiogenesis; VEGF; bone repair
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
