Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effects of Modifications on the Immunosuppressive Properties of Cyclolinopeptide A and its Analogs in Animal Experimental Models

Version 1 : Received: 17 March 2021 / Approved: 19 March 2021 / Online: 19 March 2021 (12:53:06 CET)

A peer-reviewed article of this Preprint also exists.

Zimecki, M.; Kaczmarek, K. Effects of Modifications on the Immunosuppressive Properties of Cyclolinopeptide A and Its Analogs in Animal Experimental Models. Molecules 2021, 26, 2538. Zimecki, M.; Kaczmarek, K. Effects of Modifications on the Immunosuppressive Properties of Cyclolinopeptide A and Its Analogs in Animal Experimental Models. Molecules 2021, 26, 2538.

Journal reference: Molecules 2021, 26, 2538
DOI: 10.3390/molecules26092538

Abstract

The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds and its linear precursor on their biological activities and mechanisms of action are reviewed. The modifications included truncation of the peptide chain, replacement of amino acid residues with proteinogenic or non-proteinogenic ones, modifications of peptide bond, and others. The studies revealed changes in the immunosuppressive potency of these analogs investigated in a number of in vitro and in vivo experimental models, predominantly in rodents, as well as differences in their postulated mechanism of action. The modified peptides were compared with cyclosporine A and parent CLA. Some of the synthesized and investigated peptides show potential therapeutic usefulness.

Keywords

cyclolinopeptide A; cyclosporine A; immunosuppression; PGE2; edge-to-face; cis-peptide bond; homo amino acids

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