Version 1
: Received: 12 March 2021 / Approved: 12 March 2021 / Online: 12 March 2021 (21:25:35 CET)
How to cite:
Piórkowska, K.; Żukowski, K.; Ropka-Molik, K.; Tyra, M. Long-non Coding RNAs Related to Fat Deposition in Pigs Included lncRNA Corresponding to Human MALAT1. Preprints2021, 2021030356. https://doi.org/10.20944/preprints202103.0356.v1
Piórkowska, K.; Żukowski, K.; Ropka-Molik, K.; Tyra, M. Long-non Coding RNAs Related to Fat Deposition in Pigs Included lncRNA Corresponding to Human MALAT1. Preprints 2021, 2021030356. https://doi.org/10.20944/preprints202103.0356.v1
Piórkowska, K.; Żukowski, K.; Ropka-Molik, K.; Tyra, M. Long-non Coding RNAs Related to Fat Deposition in Pigs Included lncRNA Corresponding to Human MALAT1. Preprints2021, 2021030356. https://doi.org/10.20944/preprints202103.0356.v1
APA Style
Piórkowska, K., Żukowski, K., Ropka-Molik, K., & Tyra, M. (2021). Long-non Coding RNAs Related to Fat Deposition in Pigs Included lncRNA Corresponding to Human MALAT1. Preprints. https://doi.org/10.20944/preprints202103.0356.v1
Chicago/Turabian Style
Piórkowska, K., Katarzyna Ropka-Molik and Mirosław Tyra. 2021 "Long-non Coding RNAs Related to Fat Deposition in Pigs Included lncRNA Corresponding to Human MALAT1" Preprints. https://doi.org/10.20944/preprints202103.0356.v1
Abstract
Obesity is a problem in the last decades since the development of different technologies forced the submission of a faster pace of life, resulting in nutrition style changes. In turn, domestic pigs are an excellent animal model in recognition of adiposity-related processes, corresponding to the size of individual organs, the distribution of body fat in the organism, and similar metabolism. The present study applied the next-generation sequencing method to identify adipose tissue (AT) transcriptomic signals related to increased fat content by identifying differentially expressed genes (DEGs), included long-non coding RNA molecules. The Freiburg RNA tool was applied to recognise predicting hybridisation energy of RNA-RNA interactions. The results indicated several long non-coding RNAs (lncRNAs) whose expression was significantly positively or negatively associated with fat deposition. lncRNAs play an essential role in regulating gene expression by sponging miRNA, binding transcripts, facilitating translation, or coding other smaller RNA regulatory elements. In the pig fat tissue of obese group, increased expression of lncRNAs corresponding to human MALAT1 was observed that previously recognised in the obesity-related context. Moreover, hybridisation energy analyses pinpointed numerous potential interactions between identified differentially expressed lncRNAs, and obesity-related genes and miRNAs expressed in AT.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
