Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Overexpression of p75NTR in Testicular Germ Cell Tumors: a New Biomarker of Cancer Differentiation?

Version 1 : Received: 8 March 2021 / Approved: 9 March 2021 / Online: 9 March 2021 (14:52:34 CET)

How to cite: Perri, A.; Rago, V.; Malivindi, R.; Maltese, L.; Lofaro, D.; Greco, E.A.; Tucci, L.; Bonofiglio, R.; Vergine, M.; La Vignera, S.; Chiefari, E.; Brunetti, A.; Aversa, A. Overexpression of p75NTR in Testicular Germ Cell Tumors: a New Biomarker of Cancer Differentiation?. Preprints 2021, 2021030273 (doi: 10.20944/preprints202103.0273.v1). Perri, A.; Rago, V.; Malivindi, R.; Maltese, L.; Lofaro, D.; Greco, E.A.; Tucci, L.; Bonofiglio, R.; Vergine, M.; La Vignera, S.; Chiefari, E.; Brunetti, A.; Aversa, A. Overexpression of p75NTR in Testicular Germ Cell Tumors: a New Biomarker of Cancer Differentiation?. Preprints 2021, 2021030273 (doi: 10.20944/preprints202103.0273.v1).

Abstract

Several studies have demonstrated that the p75NTR low-affinity receptor of Nerve Growth Factor (NGF), is produced in abnormally large amounts in several human cancer types. However, the role of p75NTR varies substantially depending on cell context, so that a dual role of this receptor protein in tumor cell survival and invasion, as well as cell death, has been supported in recent studies. Herein we explored for the first time the expression of p75NTR in human specimens (nr=40) from testicular germ cell tumors (TGCTs), mostly seminomas. Nuclear overexpression of p75NTR was detected by immunohistochemistry in tumor tissue as compared to normal tissue, whereas neither NGF nor its high-affinity TrkA receptor was detected. An increased nuclear staining of phospho-JNK, belonging to the p75NTR signaling pathway, and its pro-apoptotic target gene, p53, was concomitantly observed. Interestingly, our analysis revealed that decreased expression frequency of p75NTR, p-JNK, and p53 was related to staging progression, thus suggesting that p75NTR may represent a specific marker of differentiation in TGCTs.

Subject Areas

testicular germ cell tumors (TGCTs); human seminoma; p75 neurotrophin receptor (p75NTR); p75NTR -signaling.

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