Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases

Version 1 : Received: 4 March 2021 / Approved: 8 March 2021 / Online: 8 March 2021 (13:35:25 CET)

How to cite: Bohannon, D.; Long, D.; Kim, W. Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases. Preprints 2021, 2021030219 (doi: 10.20944/preprints202103.0219.v1). Bohannon, D.; Long, D.; Kim, W. Understanding the Heterogeneity of Human Pericyte Subsets in Blood-Brain Barrier Homeostasis and Neurological Diseases. Preprints 2021, 2021030219 (doi: 10.20944/preprints202103.0219.v1).

Abstract

Pericytes are increasingly recognized as being important in the control of blood-brain barrier permeability and vascular flow. Research on this important cell type has been hindered by widespread confusion regarding the phenotypic identity and nomenclature of pericytes and other perivascular cell types. In addition, pericyte heterogeneity and mouse-human species differences have contributed to confusion. Herein we summarize our present knowledge on the identification of pericytes and pericyte subsets in humans, primarily focusing on recent findings in humans and nonhuman primates. Precise identification and definition of pericytes and pericyte subsets in humans may help us to better understand pericyte biology and develop new therapeutic approaches specifically targeting disease-associated pericyte subsets.

Subject Areas

Alzheimer’s disease; blood-brain barrier; endothelial cell; laminin; multiple sclerosis; pericyte; perivascular macrophage; sonic hedgehog; vascular smooth muscle cell

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