Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Contemporary Mouse Models in Glioma Research

Version 1 : Received: 1 March 2021 / Approved: 2 March 2021 / Online: 2 March 2021 (12:54:59 CET)

A peer-reviewed article of this Preprint also exists.

Hicks, W.H.; Bird, C.E.; Traylor, J.I.; Shi, D.D.; El Ahmadieh, T.Y.; Richardson, T.E.; McBrayer, S.K.; Abdullah, K.G. Contemporary Mouse Models in Glioma Research. Cells 2021, 10, 712. https://doi.org/10.3390/cells10030712 Hicks, W.H.; Bird, C.E.; Traylor, J.I.; Shi, D.D.; El Ahmadieh, T.Y.; Richardson, T.E.; McBrayer, S.K.; Abdullah, K.G. Contemporary Mouse Models in Glioma Research. Cells 2021, 10, 712. https://doi.org/10.3390/cells10030712

Journal reference: Cells 2021, 10
DOI: 10.3390/cells10030712

Abstract

Despite advances in understanding of the molecular pathogenesis of glioma, outcomes remain dismal. Developing successful treatments for glioma requires faithful in vivo disease modeling and rigorous preclinical testing. Murine models, including xenograft, syngeneic, and genetically engineered models, are used to study gliomagenesis, identify methods of tumor progression, and test novel treatment strategies. Since the discovery of highly recurrent isocitrate dehydrogenase (IDH) mutations in lower-grade gliomas, there is increasing emphasis on effective modeling of IDH mutant brain tumors. Improvements in preclinical models that capture the phenotypic and molecular heterogeneity of gliomas are critical for the development of effective new therapies. Herein, we explore the current status, advancements, and challenges with contemporary murine glioma models.

Subject Areas

glioma; GEMM; isocitrate dehydrogenase; PDX; mouse model

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