Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review

Ezequiel Coscueta; Ana Sofia Sousa; Celso Reis; Manuela Pintado

doi:10.20944/preprints202102.0592.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 23 February 2021 / Approved: 25 February 2021 / Online: 25 February 2021 (17:03:03 CET)

The incidence of gastrointestinal diseases (cancer in particular) has increased progressively with considerable morbidity, mortality, and a high economic impact on the healthcare system. Dietary intake of natural bioactive phytochemicals showed to have cancer-preventing and therapeutic effects. This includes the cruciferous vegetable derivative phenethyl isothiocyanate (PEITC), a bioactive compound from watercress. PEITC antioxidant, anti-inflammatory and anti-cancer properties are of particular importance. This review summarizes the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discuss the safe and recommended dose of PEITC. Besides, we establish a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural nutraceutical for industrial use. This is a topic that still needs more scientific development, but with the potential to lead to a viable strategy in the prevention of cancer and other associated diseases of the gastrointestinal tract.

gastrointestinal diseases; nutraceutical; natural anti-inflammatory; natural antioxidant; watercress

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Phenethyl Isothiocyanate, a Bioactive Agent for Gastrointestinal Health: A Review

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