Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Inactivating SARS-CoV-2 Using 275nm UV-C LEDs through a Spherical Irradiation Box: Design, Characterization and Validation

Version 1 : Received: 24 February 2021 / Approved: 25 February 2021 / Online: 25 February 2021 (14:44:22 CET)

How to cite: Trivellin, N.; Buffolo, M.; Onelia, F.; Pizzolato, A.; Barbato, M.; Orlandi, V.T.; Del Vecchio, C.; Dughiero, F.; Zanoni, E.; Meneghesso, G.; Crisanti, A.; Meneghini, M. Inactivating SARS-CoV-2 Using 275nm UV-C LEDs through a Spherical Irradiation Box: Design, Characterization and Validation. Preprints 2021, 2021020588 (doi: 10.20944/preprints202102.0588.v1). Trivellin, N.; Buffolo, M.; Onelia, F.; Pizzolato, A.; Barbato, M.; Orlandi, V.T.; Del Vecchio, C.; Dughiero, F.; Zanoni, E.; Meneghesso, G.; Crisanti, A.; Meneghini, M. Inactivating SARS-CoV-2 Using 275nm UV-C LEDs through a Spherical Irradiation Box: Design, Characterization and Validation. Preprints 2021, 2021020588 (doi: 10.20944/preprints202102.0588.v1).

Abstract

We report on the design, characterization and validation of a spherical irradiation system for inactivating SARS-CoV-2, based on UV-C 275 nm LEDs. The system is designed to maximize ir-radiation intensity and uniformity, and can be used for irradiating a volume of 18 liters. To this aim: (i) several commercially available LEDs have been acquired and analyzed; (ii) a complete optical study has been carried out in order to optimize the efficacy of the system. (iii) The re-sulting prototype has been characterized optically, and tested for the inactivation of SARS-CoV-2 for different exposure times, doses and surface types. Results indicate that a 99.9% inactivation can be reached after 1 minute of treatment with a dose of 83.1 J/m2.

Subject Areas

SARS-CoV-2; Covid-19; LED; UVC; disinfection; inactivation; virucide

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