Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

CircRNA-Protein Interactions in Muscle Development and Diseases

Version 1 : Received: 23 February 2021 / Approved: 25 February 2021 / Online: 25 February 2021 (10:09:04 CET)

A peer-reviewed article of this Preprint also exists.

Zheng, S.; Zhang, X.; Odame, E.; Xu, X.; Chen, Y.; Ye, J.; Zhou, H.; Dai, D.; Kyei, B.; Zhan, S.; Cao, J.; Guo, J.; Zhong, T.; Wang, L.; Li, L.; Zhang, H. CircRNA—Protein Interactions in Muscle Development and Diseases. Int. J. Mol. Sci. 2021, 22, 3262. Zheng, S.; Zhang, X.; Odame, E.; Xu, X.; Chen, Y.; Ye, J.; Zhou, H.; Dai, D.; Kyei, B.; Zhan, S.; Cao, J.; Guo, J.; Zhong, T.; Wang, L.; Li, L.; Zhang, H. CircRNA—Protein Interactions in Muscle Development and Diseases. Int. J. Mol. Sci. 2021, 22, 3262.

Journal reference: Int. J. Mol. Sci. 2021, 22, 3262
DOI: 10.3390/ijms22063262

Abstract

Muscle is one of the most critical organs for mammals, which governs multiple movement and physiological functions. Circular RNA (circRNA) is a kind of novel endogenous RNA without 5'-Caps and 3'-poly(A) structures formed by pre-mRNA's back-splicing. RNA binding proteins (RBPs) control the production and degradation of circRNA, help nucleus-cytoplasm transport and locate circRNA, and regulate circRNA translation. Therefore, circRNAs and the chaperoned RBPs play critical roles in muscle growth, development, and disease progression. In this review, we systematically characterize the possible molecular mechanism of circRNA-protein interactions. Also, we summarize the latest researches on circRNA-protein interactions in muscle development and diseases. Besides, we provide several valid prediction methods and experimental verification approaches. Our review reveals the importance of circRNAs and their protein chaperones and provides a reference for further study in this field.

Subject Areas

muscle; circRNA; RNA binding protein; molecular interactions; function

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