Version 1
: Received: 16 February 2021 / Approved: 18 February 2021 / Online: 18 February 2021 (10:21:38 CET)
How to cite:
Zhang, Q.; Liu, F.; Zeng, M.; Xin, C.; Zhang, J.; Mao, Y.; Song, Z. Drug Repurposing Strategies in the Discovery of Antifungal Agents. Preprints2021, 2021020405. https://doi.org/10.20944/preprints202102.0405.v1
Zhang, Q.; Liu, F.; Zeng, M.; Xin, C.; Zhang, J.; Mao, Y.; Song, Z. Drug Repurposing Strategies in the Discovery of Antifungal Agents. Preprints 2021, 2021020405. https://doi.org/10.20944/preprints202102.0405.v1
Zhang, Q.; Liu, F.; Zeng, M.; Xin, C.; Zhang, J.; Mao, Y.; Song, Z. Drug Repurposing Strategies in the Discovery of Antifungal Agents. Preprints2021, 2021020405. https://doi.org/10.20944/preprints202102.0405.v1
APA Style
Zhang, Q., Liu, F., Zeng, M., Xin, C., Zhang, J., Mao, Y., & Song, Z. (2021). Drug Repurposing Strategies in the Discovery of Antifungal Agents. Preprints. https://doi.org/10.20944/preprints202102.0405.v1
Chicago/Turabian Style
Zhang, Q., Yingyu Mao and Zhangyong Song. 2021 "Drug Repurposing Strategies in the Discovery of Antifungal Agents" Preprints. https://doi.org/10.20944/preprints202102.0405.v1
Abstract
The morbidity and mortality caused by invasive fungal infections is increasing across the globe due to developments in transplant surgery, the use of immunosuppressive agents, and the emergence of drug-resistant fungal strains, which has led to a challenge in terms of treatment due to the limitations of three classes of drugs. Hence, it is imperative to establish effective strategies to identify and design new antifungal drugs. Drug repurposing is an effective way of expanding the application of existing drugs. In the last years, various existing drugs have been shown to be useful in the prevention and treatment of the invasive fungi. In this review, we summarize the currently used antifungal agents. In addition, the most up to date information on the effectiveness of existing drugs with antifungal activity is discussed. Moreover, the antifungal mechanisms of existing drugs are highlighted. These data will provide valuable knowledge to stimulate further investigation and clinical application in this field.
Keywords
drug repurposing; antifungal therapy; antifungal mechanism; clinical application; antifungal agents
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
