Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Bacteria-Bacteriophage Cycles Facilitate Cholera Outbreak Cycles: An Indirect Susceptible - Infected - Bacteria - Phage (Isibp) Model-Based Mathematical Study

Version 1 : Received: 15 February 2021 / Approved: 17 February 2021 / Online: 17 February 2021 (09:44:31 CET)

How to cite: Al Habees, A.; Aldabbas, E.; Bragazzi, N.; Kong, J. Bacteria-Bacteriophage Cycles Facilitate Cholera Outbreak Cycles: An Indirect Susceptible - Infected - Bacteria - Phage (Isibp) Model-Based Mathematical Study. Preprints 2021, 2021020357 (doi: 10.20944/preprints202102.0357.v1). Al Habees, A.; Aldabbas, E.; Bragazzi, N.; Kong, J. Bacteria-Bacteriophage Cycles Facilitate Cholera Outbreak Cycles: An Indirect Susceptible - Infected - Bacteria - Phage (Isibp) Model-Based Mathematical Study. Preprints 2021, 2021020357 (doi: 10.20944/preprints202102.0357.v1).

Abstract

Cholera is an acute enteric infectious disease caused by the Gram-negative bacterium Vibrio Cholerae. Despite a huge body of research, the precise nature of its transmission dynamics has yet to be fully elucidated. Mathematical models can be useful to better understand how an infectious agent can spread and be properly controlled. We develop a compartmental model describing a Human population, a bacterial population as well as a phage population. We show that there might be eight equilibrium points; one of which is a disease free equilibrium point. We carry out numerical simulations and sensitivity analyses and we show that the presence of phage can reduce the number of infectious individuals. Moreover, we discuss the main implications in terms of public health management and control strategies.

Subject Areas

Cholera; Bacteriophage; phage; Vibrio Cholerae; Sensitivity analysis; epidermic

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