Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Sub-Millisecond Integrated Mix-and-Inject Microfluidic Sample Delivery Devices

Version 1 : Received: 5 February 2021 / Approved: 8 February 2021 / Online: 8 February 2021 (12:12:47 CET)

How to cite: Hejazian, M.; Balaur, E.; Abbey, B. Sub-Millisecond Integrated Mix-and-Inject Microfluidic Sample Delivery Devices. Preprints 2021, 2021020199 (doi: 10.20944/preprints202102.0199.v1). Hejazian, M.; Balaur, E.; Abbey, B. Sub-Millisecond Integrated Mix-and-Inject Microfluidic Sample Delivery Devices. Preprints 2021, 2021020199 (doi: 10.20944/preprints202102.0199.v1).

Abstract

Microfluidic devices which integrate both rapid mixing and liquid jetting for sample delivery are an emerging solution for studying molecular dynamics via X-ray diffraction. Here we use finite element modelling to investigate the efficiency and time-resolution achievable using microfluidic mixers within the parameter range required for producing stable liquid jets. Three-dimensional simulations, validated by experimental data, are used to determine the velocity and concentration distribution within these devices. The results show that by adopting a serpentine geometry, it is possible to induce chaotic mixing, which effectively reduces the time required to achieve a homogeneous mixture for sample delivery. Further, we investigate the effect of flow rate and the mixer microchannel size on the mixing efficiency and minimum time required for complete mixing of the two solutions whilst maintaining a stable jet. In general, we find that the smaller the cross-sectional area of the mixer microchannel, the shorter the time needed to achieve homogeneous mixing for a given flow rate. The results of these simulations will form the basis for optimised designs enabling the study of molecular dynamics occurring on millisecond timescales using integrated mix-and-inject microfluidic devices.

Subject Areas

Microfluidics; Micro-Jet; Sub-millisecond mixing; Simulation; Sample delivery for XFEL

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.