Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Soy-enriched bread, a pilot study to determine its beneficial effects in menopause

Version 1 : Received: 28 January 2021 / Approved: 29 January 2021 / Online: 29 January 2021 (06:05:18 CET)

How to cite: Giustarini, D.; Ricci, C.; Ceccarelli, I.; Pieretti, S.; Andre, P.; Migliorini, S.; Massai, L.; Minosi, P.; Casini, I.; Aloisi, A.M. Soy-enriched bread, a pilot study to determine its beneficial effects in menopause. Preprints 2021, 2021010601 (doi: 10.20944/preprints202101.0601.v1). Giustarini, D.; Ricci, C.; Ceccarelli, I.; Pieretti, S.; Andre, P.; Migliorini, S.; Massai, L.; Minosi, P.; Casini, I.; Aloisi, A.M. Soy-enriched bread, a pilot study to determine its beneficial effects in menopause. Preprints 2021, 2021010601 (doi: 10.20944/preprints202101.0601.v1).

Abstract

Menopause is the last step in the reproductive history of a woman. The ovaries stop producing hormones and the body reacts by lowering its functions, including the neuronal one. Phytoestrogens are plant products with estrogen-like activity able to affect many body functions. The aim of the present experiment was to study the effects of 30 days of regular consumption of a soy-enriched bread containing a known amount of phytoestrogens (genistein and daidzein). Women at climacteric, within 5 years or more than 5 years of menopause, were asked to include in their diet 200 g/day of a bread containing 40 mg of phytoestrogens. The effect on common menopausal symptoms and neurophysiological, hormonal and antioxidant parameters were determined before and after 30 days through questionnaires and experimental tests. Phytoestrogens were measured in the urine. In all groups, there was a significant increase of phytoestrogens in the urine and a decrease of the classical symptoms of menopause as well as a significant improvement in attentional performance tests, the quality of life index and pain intensity. Phytoestrogens present in the soy-enriched bread, are an important supplement in aging women due to their ability to induce estrogen-like effects without the potential side effects of estrogens.

Subject Areas

menopause, women, phytoestrogens, bread, soy

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