Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Soy-enriched bread, a pilot study to determine its beneficial effects in menopause

Daniela Giustarini
ORCID logo ,
Comasia Ricci
,
Ilaria Ceccarelli
,
Stefano Pieretti
ORCID logo ,
Paolo Andre
,
Silvia Migliorini
,
Lauretta Massai
,
Paola Minosi
,
Ilenia Casini
,
Anna Maria Aloisi
*
Version 1 : Received: 28 January 2021 / Approved: 29 January 2021 / Online: 29 January 2021 (06:05:18 CET)

How to cite: Giustarini, D.; Ricci, C.; Ceccarelli, I.; Pieretti, S.; Andre, P.; Migliorini, S.; Massai, L.; Minosi, P.; Casini, I.; Aloisi, A.M. Soy-enriched bread, a pilot study to determine its beneficial effects in menopause. Preprints 2021, 2021010601. https://doi.org/10.20944/preprints202101.0601.v1 Giustarini, D.; Ricci, C.; Ceccarelli, I.; Pieretti, S.; Andre, P.; Migliorini, S.; Massai, L.; Minosi, P.; Casini, I.; Aloisi, A.M. Soy-enriched bread, a pilot study to determine its beneficial effects in menopause. Preprints 2021, 2021010601. https://doi.org/10.20944/preprints202101.0601.v1

Abstract

Menopause is the last step in the reproductive history of a woman. The ovaries stop producing hormones and the body reacts by lowering its functions, including the neuronal one. Phytoestrogens are plant products with estrogen-like activity able to affect many body functions. The aim of the present experiment was to study the effects of 30 days of regular consumption of a soy-enriched bread containing a known amount of phytoestrogens (genistein and daidzein). Women at climacteric, within 5 years or more than 5 years of menopause, were asked to include in their diet 200 g/day of a bread containing 40 mg of phytoestrogens. The effect on common menopausal symptoms and neurophysiological, hormonal and antioxidant parameters were determined before and after 30 days through questionnaires and experimental tests. Phytoestrogens were measured in the urine. In all groups, there was a significant increase of phytoestrogens in the urine and a decrease of the classical symptoms of menopause as well as a significant improvement in attentional performance tests, the quality of life index and pain intensity. Phytoestrogens present in the soy-enriched bread, are an important supplement in aging women due to their ability to induce estrogen-like effects without the potential side effects of estrogens.

Keywords

menopause, women, phytoestrogens, bread, soy

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.