Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

Version 1 : Received: 19 January 2021 / Approved: 21 January 2021 / Online: 21 January 2021 (15:01:17 CET)

How to cite: D. Alvites, R.; Vieira Branquinho, M.; Sousa, A.C.; Lopes, B.; Sousa, P.; Mendonça, C.; Atayde, L.M.; Maurício, A.C. Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.. Preprints 2021, 2021010425 (doi: 10.20944/preprints202101.0425.v1). D. Alvites, R.; Vieira Branquinho, M.; Sousa, A.C.; Lopes, B.; Sousa, P.; Mendonça, C.; Atayde, L.M.; Maurício, A.C. Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.. Preprints 2021, 2021010425 (doi: 10.20944/preprints202101.0425.v1).

Abstract

Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

Subject Areas

Goat; Sheep; Small Ruminants; Animal Models; Regenerative Medicine.

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.