Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Flavonoids: Potential Candidates for the Treatment of Neuro-Degenerative Disorders

Version 1 : Received: 19 January 2021 / Approved: 19 January 2021 / Online: 19 January 2021 (14:02:03 CET)

A peer-reviewed article of this Preprint also exists.

Devi, S.; Kumar, V.; Singh, S.K.; Dubey, A.K.; Kim, J.-J. Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders. Biomedicines 2021, 9, 99. Devi, S.; Kumar, V.; Singh, S.K.; Dubey, A.K.; Kim, J.-J. Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders. Biomedicines 2021, 9, 99.

Journal reference: Biomedicines 2021, 9, 99
DOI: 10.3390/biomedicines9020099

Abstract

Neurodegenerative disorders such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyloidal lateral sclerosis (ALS), and Huntington disease (HD) are the most concerned disorders due to the lack of effective therapeutics and dramatic rise in affected cases. Although these disorders have diverse clinical manifestations, yet they all share a common cellular stress response. These cellular stress responses including neuroinflammation, oxidative stress, proteotoxicity, and ER-stress, which combats with stress conditions, but the overwhelming cellular stress response induces cell damage. Small molecules such as flavonoids could reduce cellular stress and have gained much attention in recent years. Evidence has shown the potential use of flavonoids in several ways such as antioxidants, anti-inflammatory, and anti-apoptotic, yet their mechanism is still elusive. This review provides an insight into the mechanistic ways of flavonoids against cellular stress response that prevent the pathogenesis of neurodegenerative disorders.

Subject Areas

flavonoids; cellular stress response; neurodegenerative disorders; ER stress proteotoxicity; oxidative stress; neuroinflammation

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