Review
Version 1
Preserved in Portico This version is not peer-reviewed
Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease – The Union of Two Culprits
Version 1
: Received: 31 December 2020 / Approved: 31 December 2020 / Online: 31 December 2020 (15:34:29 CET)
A peer-reviewed article of this Preprint also exists.
Emhmed Ali, S.; Nguyen, M.H. Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits. Life 2021, 11, 119. Emhmed Ali, S.; Nguyen, M.H. Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits. Life 2021, 11, 119.
Abstract
Non-alcoholic fatty liver disease (NAFLD) continues to rise and has become the most common cause of chronic liver disease among all ages and ethnicities. Metabolic disorders such as obesity and insulin resistance are closely associated with sarcopenia and NAFLD. Sarcopenic obesity is a clinical disorder characterized by the simultaneous loss of skeletal muscle and gain of adipose tissue. It is associated with worse outcomes in individuals with NAFLD. It is projected that NAFLD and sarcopenia will rise as the prevalence of obesity continues to increase at an unparallel rate. Recently, sarcopenia and sarcopenic obesity have gained considerable interest, but we still lack a well-defined definition and a management approach. Therefore, it is imperative to continue shining the light on this topic and better understand the underlying mechanism as well as treatment options. In this review article, we aimed to address the pathophysiology, impact, and outcomes of sarcopenic obesity on NAFLD.
Keywords
Sarcopenia; Non-alcoholic Fatty Liver Disease; Obesity, Insulin Resistance; Prevalence; Metabolic Diseases
Subject
Medicine and Pharmacology, Gastroenterology and Hepatology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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