Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease – The Union of Two Culprits

Version 1 : Received: 31 December 2020 / Approved: 31 December 2020 / Online: 31 December 2020 (15:34:29 CET)

How to cite: Emhmed Ali, S.; Nguyen, M.H. Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease – The Union of Two Culprits. Preprints 2020, 2020120822 (doi: 10.20944/preprints202012.0822.v1). Emhmed Ali, S.; Nguyen, M.H. Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease – The Union of Two Culprits. Preprints 2020, 2020120822 (doi: 10.20944/preprints202012.0822.v1).

Abstract

Non-alcoholic fatty liver disease (NAFLD) continues to rise and has become the most common cause of chronic liver disease among all ages and ethnicities. Metabolic disorders such as obesity and insulin resistance are closely associated with sarcopenia and NAFLD. Sarcopenic obesity is a clinical disorder characterized by the simultaneous loss of skeletal muscle and gain of adipose tissue. It is associated with worse outcomes in individuals with NAFLD. It is projected that NAFLD and sarcopenia will rise as the prevalence of obesity continues to increase at an unparallel rate. Recently, sarcopenia and sarcopenic obesity have gained considerable interest, but we still lack a well-defined definition and a management approach. Therefore, it is imperative to continue shining the light on this topic and better understand the underlying mechanism as well as treatment options. In this review article, we aimed to address the pathophysiology, impact, and outcomes of sarcopenic obesity on NAFLD.

Subject Areas

Sarcopenia; Non-alcoholic Fatty Liver Disease; Obesity, Insulin Resistance; Prevalence; Metabolic Diseases

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