Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

The Role of Biomaterials in Upper Digestive Tract Transoral Reconstruction

Raluca Grigore
,
Bogdan Popescu
* ORCID logo ,
Serban Vifor Gabriel Bertesteanu
,
Cornelia Nichita
,
Irina Doinita Oasa
,
Gloria Simona Munteanu
,
Alexandru Nicolaescu
,
Paula Luiza Bejenaru
,
Catrinel Beatrice Simion Antonie
,
Dragos Ene
,
Razvan Ene
Version 1 : Received: 26 December 2020 / Approved: 28 December 2020 / Online: 28 December 2020 (11:24:53 CET)

A peer-reviewed article of this Preprint also exists.

Grigore, R.; Popescu, B.; Berteşteanu, Ş.V.G.; Nichita, C.; Oașă, I.D.; Munteanu, G.S.; Nicolaescu, A.; Bejenaru, P.L.; Simion-Antonie, C.B.; Ene, D.; Ene, R. The Role of Biomaterials in Upper Digestive Tract Transoral Reconstruction. Materials 2021, 14, 1436. Grigore, R.; Popescu, B.; Berteşteanu, Ş.V.G.; Nichita, C.; Oașă, I.D.; Munteanu, G.S.; Nicolaescu, A.; Bejenaru, P.L.; Simion-Antonie, C.B.; Ene, D.; Ene, R. The Role of Biomaterials in Upper Digestive Tract Transoral Reconstruction. Materials 2021, 14, 1436.

Abstract

This study aims to establish whether the use of biomaterials, particularly polydimethylsiloxane (PDMS), for surgical reconstruction of the esophagus with templates, Montgomery salivary tube, after radical oncology surgery for malignant neoplasia is an optimal choice for patients’ safety and for optimal function preservation and organ rehabilitation. Methods: Structural analysis by Raman spectrometry and biomechanical properties with dynamic mechanical analysis are performed for fatigue strength and toughness, essential factors in durability of a prosthesis in the reconstruction practice of the esophagus. Nanocomposites with silicone elastomers and nanoparticles used in implantable devices and in the reconstruction surgery are facing risks of infection and fatigue strength when required to perform a mechanical effort for long periods of time. Results: This report takes into account the effect of silver (Ag) nanoparticles on the fatigue strength using polydimethylsiloxane (PDMS) matrix, representative for silicon elastomers used in implantable devices. PDMS with 5% (wt) Ag nanoparticles of 100-150 nm during mechanical fatigue testing at shear strength loses elasticity properties after 400 loading-unloading cycles and up to 15% shear strain. The fatigue strength, toughness, maximum shear strength are the key issues in designing Montgomery salivary tube with appropriate biomechanical behavior for each patient. Conclusions: Prosthesis design needs to indulge both clinical outcome as well as design methods and research in the field of biomaterials.

Keywords

malignant neoplasia; transoral reconstruction; polydimethyl siloxane; Ag nanoparticles; fatigue strenght; prosthesis

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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