Preprint Short Note Version 1 Preserved in Portico This version is not peer-reviewed

Future Considerations for the mRNA–Lipid Nanoparticle Vaccine Platform

Version 1 : Received: 17 December 2020 / Approved: 21 December 2020 / Online: 21 December 2020 (10:26:54 CET)
Version 2 : Received: 23 December 2020 / Approved: 24 December 2020 / Online: 24 December 2020 (13:51:51 CET)

A peer-reviewed article of this Preprint also exists.

Igyártó, B. Z.; Jacobsen, S.; Ndeupen, S. Future Considerations for the mRNA-Lipid Nanoparticle Vaccine Platform. Current Opinion in Virology, 2021, 48, 65–72. https://doi.org/10.1016/j.coviro.2021.03.008. Igyártó, B. Z.; Jacobsen, S.; Ndeupen, S. Future Considerations for the mRNA-Lipid Nanoparticle Vaccine Platform. Current Opinion in Virology, 2021, 48, 65–72. https://doi.org/10.1016/j.coviro.2021.03.008.

Abstract

Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new vaccine platform used by two of the leading vaccine candidates against coronavirus disease in 2019 (COVID-19). However, there are many questions regarding their mechanism of action in humans that remain unanswered. Here we consider the immunological features of LNP components and off-target effects of the mRNA, both of which could increase the risk of side effects. We suggest ways to mitigate these potential risks by harnessing dendritic cell (DC) biology.

Keywords

mRNA-LNP vaccines; side effects; dendritic cells

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

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