Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

An Update on Self-Amplifying mRNA Vaccine Development

Version 1 : Received: 16 December 2020 / Approved: 18 December 2020 / Online: 18 December 2020 (11:12:44 CET)

How to cite: Blakney, A.; Geall, A.; Ip, S. An Update on Self-Amplifying mRNA Vaccine Development. Preprints 2020, 2020120452 (doi: 10.20944/preprints202012.0452.v1). Blakney, A.; Geall, A.; Ip, S. An Update on Self-Amplifying mRNA Vaccine Development. Preprints 2020, 2020120452 (doi: 10.20944/preprints202012.0452.v1).

Abstract

This review will explore the four major pillars required for design and development of an saRNA vaccine: antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). In will report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.

Subject Areas

RNA; self-amplifying RNA; replicon; vaccine; drug delivery

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