Submitted:
16 December 2020
Posted:
18 December 2020
You are already at the latest version
Abstract
This review will explore the four major pillars required for design and development of an saRNA vaccine: antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). In will report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.
Keywords:
RNA
; self-amplifying RNA
; replicon
; vaccine
; drug delivery
Copyright: This open access article is published under a Creative Commons CC BY 4.0 license, which permit the free download, distribution, and reuse, provided that the author and preprint are cited in any reuse.
