Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Why Hyperuricemia Does Not Necessarily Induce Gout?

Version 1 : Received: 14 December 2020 / Approved: 16 December 2020 / Online: 16 December 2020 (08:30:53 CET)

A peer-reviewed article of this Preprint also exists.

Zhang, W.-Z. Why Does Hyperuricemia Not Necessarily Induce Gout? Biomolecules 2021, 11, 280. Zhang, W.-Z. Why Does Hyperuricemia Not Necessarily Induce Gout? Biomolecules 2021, 11, 280.


Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of hyperuricemia individuals have never had a gout attack(s), while some patients with gout can have a normuricemia. This raises a puzzle of the real role of serum uric acid (SUA) in the occurrence of gout attacks. As the molecule of uric acid has its dual effects in vivo with antioxidant property as well as being an inflammatory promoter, it has been placed in a delicate position in balancing metabolisms. Gout seems to be a multifactorial metabolic disease and its pathogenesis should not rely solely on hyperuricemia or MSU crystal. This critical review aims to unfold the mechanisms of the SUA role participating in gout development. It also discusses some key elements which are prerequisite for the formation of gout in association with the current therapeutic regime. The compilation should be helpful in precisely fighting for a cure of gout clinically and pharmaceutically.


Metabolism; Inflammation; uric acid; hyperuricemia; monosodium urate crystal; gout


Biology and Life Sciences, Biochemistry and Molecular Biology

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