Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mapping the Non-Structural Transmembrane Proteins of SARS-CoV-2

Version 1 : Received: 14 December 2020 / Approved: 15 December 2020 / Online: 15 December 2020 (10:13:11 CET)

How to cite: Thomas, S. Mapping the Non-Structural Transmembrane Proteins of SARS-CoV-2. Preprints 2020, 2020120366 (doi: 10.20944/preprints202012.0366.v1). Thomas, S. Mapping the Non-Structural Transmembrane Proteins of SARS-CoV-2. Preprints 2020, 2020120366 (doi: 10.20944/preprints202012.0366.v1).

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the disease COVID-19 has wreaked havoc on the health and economy of humanity. In addition, the disease is observed in domestic and wild animals. The disease has impacted directly and indirectly every corner of the planet. Currently, there are no vaccines and effective therapies for COVID-19. SARS-CoV-2 is an enveloped virus with a single-stranded RNA genome of 29.8 kb. More than two-thirds of the genome comprises Orf1ab encoding 16 non-structural proteins (nsps) followed by mRNAs encoding structural proteins, spike (S), envelop (E), membrane (M), and nucleocapsid (N). These genes are interspaced with several accessory genes (open reading frames [Orf] 3a, 3b, 6, 7a, 7b, 8, 9b, 9c and 10). The functions of these proteins are of particular interest for understanding the pathogenesis of SARS-CoV-2. Several of the nsps (nsp3, nsp4, nsp6) and Orf3a are transmembrane proteins involved in regulating the host immunity, modifying host cell organelles for viral replication and escape and hence considered drug targets. In this paper we report mapping the transmembrane structure of the non-structural proteins of SARS-CoV-2.

Subject Areas

SARS-CoV-2; COVID-19; coronavirus; non-structural proteins; nsps; nsp3; nsp4; nsp6; Orf1ab; Orf3a; endoplasmic reticulum; double membrane vesicle

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