Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence

Version 1 : Received: 7 December 2020 / Approved: 8 December 2020 / Online: 8 December 2020 (09:44:05 CET)

A peer-reviewed article of this Preprint also exists.

Centeno-Tablante, E.; Medina-Rivera, M.; Finkelstein, J.L.; Herman, H.S.; Rayco-Solon, P.; Garcia-Casal, M.N.; Rogers, L.; Ghezzi-Kopel, K.; Zambrano Leal, M.P.; Andrade Velasquez, J.K.; Chang Asinc, J.G.; Peña-Rosas, J.P.; Mehta, S. Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence. Viruses 2021, 13, 123. Centeno-Tablante, E.; Medina-Rivera, M.; Finkelstein, J.L.; Herman, H.S.; Rayco-Solon, P.; Garcia-Casal, M.N.; Rogers, L.; Ghezzi-Kopel, K.; Zambrano Leal, M.P.; Andrade Velasquez, J.K.; Chang Asinc, J.G.; Peña-Rosas, J.P.; Mehta, S. Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence. Viruses 2021, 13, 123.

Journal reference: Viruses 2021, 13, 123
DOI: 10.3390/v13010123

Abstract

To gain new insights into the potential of mother-to-child transmission of Zika virus (ZIKV) through breast milk or breastfeeding practices, we systematically searched regional and international databases and screened 1,658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant. Fourteen studies met our inclusion criteria and inform this analysis. These studies reported on 97 mother-children pairs who provided breast milk for ZIKV assessment. Seventeen breast milk samples from different women were found positive for ZIKV via RT-PCR, and ZIKV replication was found in cell cultures from five out of seven breast milk samples from different women. Only three out of six infants who had ZIKV infection were breastfed, no evidence of clinical complications were found to be associated with ZIKV RNA in breast milk. This review updates our previous report by synthesizing the evidence from 12 new articles and we find no evidence of mother-to-child transmission through breast milk intake or breastfeeding. As the certainty of the present evidence is low, additional studies are still warranted to completely understand any potential of transmission of ZIKV through breastfeeding.

Subject Areas

Zika virus; Zika virus infection; perinatal transmission; mother-to-child transmission; breast milk; breastfeeding

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