Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes

Pavel Georgiev; Olga Kyrchanova

doi:10.20944/preprints202012.0184.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 7 December 2020 / Approved: 8 December 2020 / Online: 8 December 2020 (08:29:36 CET)

In higher eukaryotes, enhancers determine the activation of developmental gene transcription in specific cell types and stages of embryogenesis. Enhancers transform the signals produced by various transcription factors within a given cell, activating the transcription of the targeted genes. Often, developmental genes can be associated with dozens of enhancers, some of which are located at large distances from the promoters that they regulate. Currently, the mechanisms that underly the specific distance interactions between enhancers and promoters remain unknown. This review describes the properties and activities of enhancers and discusses the mechanisms of distance interactions and potential proteins involved in this process.

C2H2 proteins; CTCF; LDB1; chromatin insulator; long-distance interactions

LIFE SCIENCES, Biochemistry

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Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes

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