Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Web-based Tools for Computational Enzyme Design

Version 1 : Received: 2 December 2020 / Approved: 3 December 2020 / Online: 3 December 2020 (14:33:54 CET)
Version 2 : Received: 27 January 2021 / Approved: 28 January 2021 / Online: 28 January 2021 (07:51:45 CET)

A peer-reviewed article of this Preprint also exists.

Marques, S.M.; Planas-Iglesias, J.; Damborsky, J. Web-based tools for computational enzyme design. Curr. Opin. Struct. Biol. 2021, 69, 19-34 Marques, S.M.; Planas-Iglesias, J.; Damborsky, J. Web-based tools for computational enzyme design. Curr. Opin. Struct. Biol. 2021, 69, 19-34

Journal reference: Current Opinion in Structural Biology 2021, 69, 19-34
DOI: 10.1016/j.sbi.2021.01.010

Abstract

Enzymes are on high demand for very diverse biotechnological applications. However, natural biocatalysts often need to be engineered for fine-tuning their properties towards the end applications, such as the activity, selectivity, stability to temperature or co-solvents, and solubility. Computational methods are increasingly used in this task, providing predictions that narrow down the space of possible mutations significantly and can enormously reduce the experimental burden. Many computational tools are available as web-based platforms, making them accessible to non-expert users. These platforms are typically user-friendly, contain walk-throughs, and do not require deep expertise and installations. Here we describe some of the most recent outstanding web-tools for enzyme engineering and formulate future perspectives in this field.

Subject Areas

web server; rational design; functionalizing enzymes; enzyme discovery; user-friendly tools

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