Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Are Dietary Indices Associated with Polycystic Ovary Syndrome and Its Phenotypes? A Case-Control Study

Version 1 : Received: 30 November 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (09:29:48 CET)

How to cite: Cutillas-Tolín, A.; Arense-Gonzalo, J.; Mendiola, J.; Adoamnei, E.; Navarro-Lafuente, F.; Sanchez-Ferrer, M.L.; Sanchez, M.T.P.; Carmona-Barnosi, A.; Vioque, J.; Torres-Cantero, A.M. Are Dietary Indices Associated with Polycystic Ovary Syndrome and Its Phenotypes? A Case-Control Study. Preprints 2020, 2020120053 (doi: 10.20944/preprints202012.0053.v1). Cutillas-Tolín, A.; Arense-Gonzalo, J.; Mendiola, J.; Adoamnei, E.; Navarro-Lafuente, F.; Sanchez-Ferrer, M.L.; Sanchez, M.T.P.; Carmona-Barnosi, A.; Vioque, J.; Torres-Cantero, A.M. Are Dietary Indices Associated with Polycystic Ovary Syndrome and Its Phenotypes? A Case-Control Study. Preprints 2020, 2020120053 (doi: 10.20944/preprints202012.0053.v1).

Abstract

Polycystic ovary syndrome (PCOS) is a complex hormonal disorder which impair ovarian function. The adherence to healthy dietary patterns and physical exercise are the first line of recommended treatment for PCOS patients, but it is no clear what type of diet is more adequate. In this case-control study, we explore the association between the adherence to five dietary quality indices widely used and PCOS. We enrolled 126 cases of PCOS and 159 controls (Murcia, Spain). Diagnostic of PCOS and its phenotypes were established following the Rotterdam criteria [hyperandrogenism (H), oligoanovulation (O), polycystic ovaries morphology (POM)]. We used a validated food frequency questionnaires to calculate the scores for five dietary indices: alternate Healthy Eating index (AHEI), AHEI-2010, relative Mediterranean Dietary Score (rMED), alternate Mediterranean Dietary Score (aMED) and Dietary Approaches to Stop Hypertension (DASH). We used multivariable logistic regression to estimate adjusted odds ratios and confidence intervals. In the multivariable analysis, AHEI-2010 index was inversely associated with “H+O” PCOS’ phenotype (ORQ3 VS Q1= 0.1; 95% CI :(0.0; 0.9); P for trend= 0.02). In conclusion, we did not find any statistical significative association between dietary indices and total, anovulatory and ovulatory PCOS, but it seems interesting explore these association among the diverse phenotypes of PCOS in studies with higher sample size.

Subject Areas

Polycystic Ovary Syndrome (PCOS); PCOS phenotypes; Rotterdam Criteria; hyperandrogenism; Mediterranean Diet Score (MDS); Alternate Healthy Index (AHEI); Alternate Healthy Index 2010 (AHEI-2010) and DASH index

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