Working Paper Article Version 2 This version is not peer-reviewed

The Regulation Effect of Crude Polysaccharides from Cordyceps Militaris on Obesity Control and Gut Microbiota Community via High-Fat Diet-Fed Mice Model

Version 1 : Received: 1 December 2020 / Approved: 2 December 2020 / Online: 2 December 2020 (09:20:18 CET)
Version 2 : Received: 2 December 2020 / Approved: 3 December 2020 / Online: 3 December 2020 (10:26:45 CET)

How to cite: Yu, M.; Hui, N.; Hayat, K.; Yang, X.; Chu, S.; Zhang, D.; Wang, J.; Chen, X.; Ding, J.; Chi, Y.; Zhou, P. The Regulation Effect of Crude Polysaccharides from Cordyceps Militaris on Obesity Control and Gut Microbiota Community via High-Fat Diet-Fed Mice Model. Preprints 2020, 2020120052 Yu, M.; Hui, N.; Hayat, K.; Yang, X.; Chu, S.; Zhang, D.; Wang, J.; Chen, X.; Ding, J.; Chi, Y.; Zhou, P. The Regulation Effect of Crude Polysaccharides from Cordyceps Militaris on Obesity Control and Gut Microbiota Community via High-Fat Diet-Fed Mice Model. Preprints 2020, 2020120052

Abstract

Administration of crude polysaccharides extract from natural product is a promising gut microbiota-targeted approach to preventing obesity and associated metabolic disorders. Dietary restrictions can change the type and number of gut bacteria, which is an important factor in delaying the onset and burden of diseases. This study aimed to investigate the effects of high-yield crude polysaccharides from Cordyceps militaris (CMP) on high-fat diet (HFD) mice model and the gut microbiota community assembly, and to identify whether selenium (Se) addition would improve CMP action mode during cultivation. We found that the CMP treatment ameliorated adipose and liver pathologic morphology and fat accumulation in obese mice, while, SeCMP intervention was not superior than CMP in body mass gain, but notably decreasing serum triglyceride level increased by HFD. The upregulated expression of gene Cyp7a1 in liver and protein UCP1 in brown adipose tissue (BAT) preliminary indicated that the effect might relate to bile acids (BAs) metabolism pathway and thermogenesis. In addition, CMP showed a drastic decrease in the gut microbes which positively correlated with dyslipidemia parameters. Our result reveals the potential of CMP to be used as functional food in the prevention of diet-induced adipose and liver steatosis, so does SeCMP has outstanding capacity of improving dyslipidemia.

Keywords

Cordyceps militaris; crude polysaccharides; selenium-rich crude polysaccharides; high-fat diet (HFD); obesity; dyslipidemia; hypertriglyceridemia; gut microbiota

Comments (1)

Comment 1
Received: 3 December 2020
Commenter: Pei Zhou
Commenter's Conflict of Interests: Author
Comment: Figure 5 error amended.
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