Working Paper Review Version 1 This version is not peer-reviewed

Tissue Engineering and Three-Dimensional Printing in Periodontal Regeneration

Version 1 : Received: 23 November 2020 / Approved: 24 November 2020 / Online: 24 November 2020 (16:18:17 CET)

A peer-reviewed article of this Preprint also exists.

Raveau, S.; Jordana, F. Tissue Engineering and Three-Dimensional Printing in Periodontal Regeneration: A Literature Review. J. Clin. Med. 2020, 9, 4008. Raveau, S.; Jordana, F. Tissue Engineering and Three-Dimensional Printing in Periodontal Regeneration: A Literature Review. J. Clin. Med. 2020, 9, 4008.

Journal reference: J. Clin. Med. 2020, 9, 4008
DOI: 10.3390/jcm9124008

Abstract

The three-dimensional printing of scaffolds is an interesting alternative to the traditional techniques of periodontal regeneration. This technique uses computer assisted design and manufacturing after CT scan. After 3D modelling, individualized scaffolds are printed by extrusion, selective laser sintering, stereolithography, or powder bed inkjet printing. These scaffolds can be made of one or several materials such as natural polymers, synthetic polymers, or bioceramics. They can be monophasic or multiphasic and tend to recreate the architectural structure of the periodontal tissue. In order to enhance the bioactivity and have a higher regeneration, the scaffolds can be embedded with stem cells and/or growth factors. This new technique could enhance a complete periodontal regeneration. This review summarizes the application of 3D printed scaffolds in periodontal regeneration. The process, the materials and designs, the key advantages and prospects of 3D bioprinting are highlighted, providing new ideas for tissue regeneration.

Subject Areas

3D printing; tissue engineering; periodontal regeneration; scaffolds; stem cells; growth factors

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