Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods

Version 1 : Received: 18 November 2020 / Approved: 19 November 2020 / Online: 19 November 2020 (10:41:35 CET)

How to cite: Burian, A.; Zhao, W.; Lo, T.; Thurtle-Schmidt, D. Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods . Preprints 2020, 2020110501 (doi: 10.20944/preprints202011.0501.v1). Burian, A.; Zhao, W.; Lo, T.; Thurtle-Schmidt, D. Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods . Preprints 2020, 2020110501 (doi: 10.20944/preprints202011.0501.v1).

Abstract

To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called “-omics”, have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated.

Subject Areas

genomics; sequencing; ethics; bioinformatics

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