Burian, A.; Zhao, W.; Lo, T.; Thurtle-Schmidt, D. Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods. Preprints2020, 2020110501. https://doi.org/10.20944/preprints202011.0501.v1
APA Style
Burian, A., Zhao, W., Lo, T., & Thurtle-Schmidt, D. (2020). <strong> </strong>Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods<strong> </strong>. Preprints. https://doi.org/10.20944/preprints202011.0501.v1
Chicago/Turabian Style
Burian, A., Te-Wen Lo and Deborah Thurtle-Schmidt. 2020 "<strong> </strong>Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods<strong> </strong>" Preprints. https://doi.org/10.20944/preprints202011.0501.v1
Abstract
To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called “-omics”, have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated.
Keywords
genomics; sequencing; ethics; bioinformatics
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
