Version 1
: Received: 18 November 2020 / Approved: 19 November 2020 / Online: 19 November 2020 (10:41:35 CET)
How to cite:
Burian, A.; Zhao, W.; Lo, T.; Thurtle-Schmidt, D. Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods. Preprints2020, 2020110501 (doi: 10.20944/preprints202011.0501.v1).
Burian, A.; Zhao, W.; Lo, T.; Thurtle-Schmidt, D. Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods . Preprints 2020, 2020110501 (doi: 10.20944/preprints202011.0501.v1).
Cite as:
Burian, A.; Zhao, W.; Lo, T.; Thurtle-Schmidt, D. Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods. Preprints2020, 2020110501 (doi: 10.20944/preprints202011.0501.v1).
Burian, A.; Zhao, W.; Lo, T.; Thurtle-Schmidt, D. Genome Sequencing Guide: An Introductory Toolbox to Whole-Genome Analysis Methods . Preprints 2020, 2020110501 (doi: 10.20944/preprints202011.0501.v1).
Abstract
To fully appreciate genetics, one must understand the link between genotype (DNA sequence) and phenotype (observable characteristics). Advances in high-throughput genomic sequencing technologies and applications, so-called “-omics”, have made genetic sequencing readily available across fields in biology from applications in non-traditional study organisms to precision medicine. Thus, understanding these tools is critical for any biologist, especially those early in their career. This comprehensive review discusses the chronological development of different sequencing methods, the bioinformatics steps to analyzing this data, and social and ethical issues raised by these techniques that must be discussed and evaluated.
Keywords
genomics; sequencing; ethics; bioinformatics
Subject
LIFE SCIENCES, Biochemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
