Version 1
: Received: 14 November 2020 / Approved: 16 November 2020 / Online: 16 November 2020 (11:45:34 CET)
Version 2
: Received: 14 December 2020 / Approved: 15 December 2020 / Online: 15 December 2020 (13:03:01 CET)
How to cite:
Strey, K. How Toxic indeed is Oxymetazoline? Collection and Comparison of Toxicological Data of Pharmacologically Active Imidazoline Derivatives. Preprints2020, 2020110416. https://doi.org/10.20944/preprints202011.0416.v1
Strey, K. How Toxic indeed is Oxymetazoline? Collection and Comparison of Toxicological Data of Pharmacologically Active Imidazoline Derivatives. Preprints 2020, 2020110416. https://doi.org/10.20944/preprints202011.0416.v1
Strey, K. How Toxic indeed is Oxymetazoline? Collection and Comparison of Toxicological Data of Pharmacologically Active Imidazoline Derivatives. Preprints2020, 2020110416. https://doi.org/10.20944/preprints202011.0416.v1
APA Style
Strey, K. (2020). <strong>How Toxic indeed is Oxymetazoline? Collection and Comparison of Toxicological Data of Pharmacologically Active Imidazoline Derivatives</strong>. Preprints. https://doi.org/10.20944/preprints202011.0416.v1
Chicago/Turabian Style
Strey, K. 2020 "<strong>How Toxic indeed is Oxymetazoline? Collection and Comparison of Toxicological Data of Pharmacologically Active Imidazoline Derivatives</strong>" Preprints. https://doi.org/10.20944/preprints202011.0416.v1
Abstract
Imidazoline derivatives, such as xylometazoline, naphazoline, tetryzoline, tramazoline or oxymetazoline play an important pharmacological role as nasal drops in the symptomatic treatment of rhinitis. When comparing the toxicological data of these substances, it is noticeable that Oxymetazoline has an LD50 value which is two orders of magnitude lower than all other imidazoline derivatives. Thus, ten vials of commercially available oxymetazoline nasal drops already contain a lethal amount. An explanation for this unusually high toxicity has not yet been found.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.