Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure

Version 1 : Received: 13 November 2020 / Approved: 13 November 2020 / Online: 13 November 2020 (07:32:33 CET)

How to cite: Minkler, S.; Lucien, F.; Kimber, M.; Bourgois-Mochel, A.; Musser, M.; Johannes, C.; Frank, I.; Cheville, J.; Allenspach, K.; Mochel, J. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure. Preprints 2020, 2020110364 (doi: 10.20944/preprints202011.0364.v1). Minkler, S.; Lucien, F.; Kimber, M.; Bourgois-Mochel, A.; Musser, M.; Johannes, C.; Frank, I.; Cheville, J.; Allenspach, K.; Mochel, J. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure. Preprints 2020, 2020110364 (doi: 10.20944/preprints202011.0364.v1).

Abstract

Urinary bladder cancer (UBC) is the most common malignancy of the urinary tract in humans, with an estimated global prevalence of 1.1 million cases over 5 years1. Due to high rates of recurrence and resistance to chemotherapy, UBC is one of the most expensive cancers to treat, resulting in significant health care costs. There is, therefore, a critical need to develop innovative molecular and cellular tools to refine patient stratification and help predict response to treatment. Urine is an underused resource of biological components shed from bladder tumors, such as exfoliated cells and extracellular vesicles, that could serve as molecular fingerprints and provide valuable biological insights into tumor phenotype and mechanisms of resistance to chemotherapy. Additionally, characterization of urine-derived extracellular vesicles and cells could be used as reliable biomarkers for prediction of response to neoadjuvant therapy.

Subject Areas

Bladder Cancer; Exosomes; Organoids; One Health

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