Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Post-Mortem Cardiac Magnetic Resonance for the Diagnosis of Hypertrophic Cardiomyopathy

Version 1 : Received: 29 October 2020 / Approved: 6 November 2020 / Online: 6 November 2020 (10:44:52 CET)

A peer-reviewed article of this Preprint also exists.

Aquaro, G.D.; Guidi, B.; Biondi, F.; Chiti, E.; Santurro, A.; Scopetti, M.; Turillazzi, E.; Di Paolo, M. Post-Mortem Cardiac Magnetic Resonance for the Diagnosis of Hypertrophic Cardiomyopathy. Diagnostics 2020, 10, 981. Aquaro, G.D.; Guidi, B.; Biondi, F.; Chiti, E.; Santurro, A.; Scopetti, M.; Turillazzi, E.; Di Paolo, M. Post-Mortem Cardiac Magnetic Resonance for the Diagnosis of Hypertrophic Cardiomyopathy. Diagnostics 2020, 10, 981.

Journal reference: Diagnostics 2020, 10, 981
DOI: 10.3390/diagnostics10110981

Abstract

Post-mortem cardiac magnetic resonance (PMCMR) is an emerging tool supporting forensic medicine for the identification of the causes of cardiac death, as hypertrophic cardiomyopathy (HCM). We proposed a new method of PMCMR to diagnose HCM despite myocardial rigor mortis. Methods: we performed CMR in 49 HCM patients, 30 non-HCM hypertrophy and 32 healthy controls. In cine images, rigor mortis was simulated by the analysis of the cardiac phase corresponding to the 25% of diastole. Left ventricular mass, mean and standard deviation (SD) of WT, maximal WT, minimal WT and their difference, were compared for the identification of HCM. These parameters were validated at PMCMR, evaluating 8 hearts with HCM, 10 with coronary artery disease and 10 with non-cardiac death. Results: The SD of WT with a cut-off of > 2.4 had the highest accuracy to identify HCM (AUC 0.95, 95%CI 0.89-0.98). This was particularly evident in female population of HCM (AUC=0.998), with 100% specificity (95%CI 85-100%) and 96% sensitivity (95%CI 79-99%). Using this parameter, at PMCMR all the 8 patients with HCM were correctly identified with no false positive. Conclusions: PMCMR allows to identify HCM as cause of sudden death using the SD of WT >2.4 as diagnostic parameter.

Subject Areas

Post-mortem Cardiac magnetic resonance; hypertrophic cardiomyopathy; sudden death

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.