Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair

Mehri Sohrabi
,
Bijan Eftekhari Yekta
ORCID logo ,
Hamidreza Rezaie
,
Mohammad Reza Naimi-Jamal
ORCID logo ,
Ajay Kumar
,
Andrea Cochis
ORCID logo ,
Marta Miola
ORCID logo ,
Lia Rimondini
* ORCID logo
Version 1 : Received: 4 November 2020 / Approved: 5 November 2020 / Online: 5 November 2020 (10:48:46 CET)

A peer-reviewed article of this Preprint also exists.

Sohrabi, M.; Yekta, B.E.; Rezaie, H.; Naimi-Jamal, M.R.; Kumar, A.; Cochis, A.; Miola, M.; Rimondini, L. Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair. Biomedicines 2020, 8, 616. Sohrabi, M.; Yekta, B.E.; Rezaie, H.; Naimi-Jamal, M.R.; Kumar, A.; Cochis, A.; Miola, M.; Rimondini, L. Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair. Biomedicines 2020, 8, 616.

Abstract

Bioactive glass (BG) represents a promising biomaterial for bone healing; here injectable BG pastes biological properties were improved by 25 wt% gelatin or chitosan, as well as mechanical resistance was enhanced by adding 10 or 20 wt% 3-Glycidyloxypropyl trimethoxysilane (GPTMS) cross-linker. Composites exhibited bioactivity as apatite formation was observed by SEM and XRD after 14 days immersion in SBF; moreover, polymers did not enhance degradability as weight loss was >10% after 30 days in physiological conditions. BG-gelatin-20 wt% GPTMS composites demonstrated the highest compressive strength (4.8±0.5 MPa) in comparison with 100% BG control (1.9±0.1 MPa). Cytocompatibility was demonstrated towards human mesenchymal stem cells (hMSC), osteoblasts progenitors and endothelial cells. The presence of 20 wt% GPTMS conferred antibacterial properties thus inhibiting the joint pathogens Staphylococcus aureus and Staphylococcus epidermidis infection. Finally, hMSC osteogenesis was successfully supported in a 3D model as demonstrated by alkaline phosphatase release and osteogenic genes expression.

Keywords

bioactive glass; gelatin; chitosan; 3-Glycidyloxypropyl trimethoxysilane; bone.

Subject

Chemistry and Materials Science, Biomaterials

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.